Evidence map›Paper›PMID 41342697›Full record

ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2025

The relationship between native T1 and mortality in patients requiring maintenance haemodialysis, using cardiac magnetic resonance imaging.

Sherna F Adenwalla, Rachael E Stannard, Alastair J Rankin, Daniel S March, Jennifer S Lees, Gaurav S Gulsin, Gerry P McCann, James O Burton, Patrick B Mark, Matthew Pm Graham-Brown

Registry-linked trialAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03704701 (The Interrogation of the Cardiomyopathy of Chronic Kidney Disease With advancEd caRdiac Imaging), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03704701 terminatednot on this map

The Interrogation of the Cardiomyopathy of Chronic Kidney Disease With advancEd caRdiac Imaging

TypeobservationalSponsorNHS Greater Glasgow and ClydeRan2018 to 2020Enrolled28ConditionsChronic Kidney Diseases, Cardiomyopathies, Cardiovascular Diseases, Cardiac DiseaseArmsCardiac MRI and contrast-enhanced cardiac CT
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sherna F AdenwallaDepartment of Cardiovascular Sciences, University of Leicester, UK; NIHR Leicester Biomedical Research Centre, University Hospitals of Leicester NHS Trust, Leicester, UK.
Rachael E StannardDepartment of Health Sciences, University of Leicester, Leicester, UK.
Alastair J RankinSchool of Cardiovascular and Metabolic Health, University of Glasgow, 126 University Place, Glasgow, UK; The Glasgow Renal & Transplant Unit, Queen Elizabeth University Hospital, 1345 Govan Road, Glasgow, UK.
Daniel S MarchDepartment of Cardiovascular Sciences, University of Leicester, UK; NIHR Leicester Biomedical Research Centre, University Hospitals of Leicester NHS Trust, Leicester, UK.
Jennifer S LeesSchool of Cardiovascular and Metabolic Health, University of Glasgow, 126 University Place, Glasgow, UK; The Glasgow Renal & Transplant Unit, Queen Elizabeth University Hospital, 1345 Govan Road, Glasgow, UK.
Gaurav S GulsinDepartment of Cardiovascular Sciences, University of Leicester, UK; NIHR Leicester Biomedical Research Centre, University Hospitals of Leicester NHS Trust, Leicester, UK.
Gerry P McCannDepartment of Cardiovascular Sciences, University of Leicester, UK; NIHR Leicester Biomedical Research Centre, University Hospitals of Leicester NHS Trust, Leicester, UK.
James O BurtonDepartment of Cardiovascular Sciences, University of Leicester, UK; NIHR Leicester Biomedical Research Centre, University Hospitals of Leicester NHS Trust, Leicester, UK; National Centre for Sport and Exercise Medicine, School of Sport, Exercise and Health, Loughborough University, UK.
Patrick B MarkSchool of Cardiovascular and Metabolic Health, University of Glasgow, 126 University Place, Glasgow, UK; The Glasgow Renal & Transplant Unit, Queen Elizabeth University Hospital, 1345 Govan Road, Glasgow, UK.
Matthew Pm Graham-BrownDepartment of Cardiovascular Sciences, University of Leicester, UK; NIHR Leicester Biomedical Research Centre, University Hospitals of Leicester NHS Trust, Leicester, UK. Electronic address: mgb23@le.ac.uk.

Funding

Wellcome Trust 301005/Z/23/Z
6 · The paper itself

Abstract

backgroundIn people with kidney failure requiring haemodialysis, sudden cardiac death and arrhythmia are prevalent causes of mortality, driven by left ventricular (LV) hypertrophy and myocardial fibrosis. Native T1, a non-contrast magnetic resonance imaging (MRI) technique, is thought to represent myocardial fibrosis in this population. We hypothesised that MRI measures of cardiac structure and function would associate with mortality.

methodsA post-hoc, longitudinal analysis of data from the CYCLE-HD (ISRCTN11299707) and TICKER (NCT03704701) studies examined associations between native T1, LV mass index, LV ejection fraction (LVEF), and mortality over five years in people requiring haemodialysis. Cox proportional hazard models were adjusted for age, sex, diabetes, time on dialysis, and subsequent transplant.

resultsAmong 156 participants (mean age 60, 71% [111/156] male), 71 died over five years. In adjusted models increases in T1, LV mass index, and decreases in LV ejection fraction independently associated with mortality. A 30 ms increase in native T1 conferred a 27% increased risk of death. A 1 g/m

conclusionNative T1, LV mass index, and LVEF were significant determinants of mortality in people requiring haemodialysis. T1 shows promise as a novel biomarker of myocardial fibrosis in this population. Associations between changes in T1 and mortality, and consideration of implementing findings into clinical practice needs research.

Indexed as

Magnetic Resonance ImagingMagnetic Resonance Imaging, CineMyocardiumRenal DialysisRenal InsufficiencyVentricular Function, LeftAgedFemaleFibrosisHumansLongitudinal StudiesMaleMiddle AgedPredictive Value of TestsPrognosisRisk AssessmentCardiac MRICardiovascularEnd-stage kidney diseaseGlobal native T1HaemodialysisMortality

Identifiers

PMID41342697
PMCPMC12744331

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.