RevieweLife2025
Extracellular matrices regulate extravasation journey of leukocytes and inflammatory tissue fate.
Review in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The role of extracellular matrix stiffness in regulating fibroblast behaviors and disease progression.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Leukocyte extravasation across the blood endothelium to inflamed tissues is a crucial defence mechanism against invading pathogens. After the elimination of the pathogen in the tissue, inflammation needs to be resolved back to steady state. This cascade comprises at least three stages: transmigration through the endothelium and the underlying basement membrane, intra-tissue leukocyte activity, and tissue resolution. In each stage, extracellular matrix proteins in the vascular basement membrane and in tissues regulate a multitude of endothelial and leukocyte functions essential to completion of the cascade, either as a collective force-permissive structure or through signaling by individual matrix proteins. Proper orchestration of these diverse processes during the extravasation journey ensures effective defence and avoids development of chronic inflammatory diseases. This review will focus on how these extracellular matrices regulate the extravasation journey of leukocytes to illustrate their tight functional interdependence with profound impacts on the ultimate post-inflammation tissue fate.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.