ArticleInvestigative ophthalmology & visual science2025
Scientific Concerns About Recent Fluid-Structure Interaction Models of the Aqueous Humor Outflow Pathway.
Article in Investigative ophthalmology & visual science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Bioengineered 3D Human Trabecular Meshwork Models for Outflow Physiology and Glaucoma Research.Bioengineering (Basel, Switzerland) · 2026Review
- Response to "Scientific Concerns About Recent Fluid-Structure Interaction Models of the Aqueous Humor Outflow Pathway".Investigative ophthalmology & visual science · 2025Article
- Author Response: Scientific Concerns About Recent Fluid-Structure Interaction Models of the Aqueous Humor Outflow Pathway.Investigative ophthalmology & visual science · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of sophisticated computational tools, combined with advanced ultrastructural imaging techniques, offers unprecedented opportunities to investigate aqueous humor outflow through the conventional pathway, the site of pathology responsible for ocular hypertension in glaucoma. Recently, a series of studies1-7 have used computational methods to study conventional outflow function. Regrettably, these studies1-7 appear to contain fundamental errors that lead to predictions that are inconsistent with established outflow physiology and raise concerns regarding methodology and apparent misrepresentations of published work. As a result, this body of work draws potentially misleading and erroneous conclusions about aqueous humor dynamics. It is therefore important to recognize and discuss these works to correct the archival record and avoid misdirecting future research.
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Registered trials
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