Evidence map›Paper›PMID 41342532›Full record

ArticlemSphere2025

Allele-specific effects of mutations in the rifampin resistance-determining region (RRDR) of RpoB on physiology and antibiotic resistance in

Adeline Supandy, Emma G Mills, Kyong T Fam, Ryan K Shields, Howard C Hang, Daria Van Tyne

Abstract read
In one paragraph

Article in mSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Adeline SupandyDivision of Infectious Diseases, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-0310-3139
Emma G MillsDivision of Infectious Diseases, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA.
Kyong T FamDepartment of Immunology and Microbiology, Scripps Research, La Jolla, California, USA.
Ryan K ShieldsDivision of Infectious Diseases, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-9794-5665
Howard C HangDepartment of Immunology and Microbiology, Scripps Research, La Jolla, California, USA.ORCID 0000-0003-3373-7140
Daria Van TyneDivision of Infectious Diseases, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-7284-0103

Funding

Enhanced Detection System for Healthcare-Associated Transmission of InfectionR01AI127472 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HARRISON, LEE H · 2016 to 2025
$7.6M
Adaptation of vancomycin-resistant enterococci during bloodstream infectionR01AI165519 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VAN TYNE, DARIA N · 2022 to 2025
$3.0M
National Institute of Allergy and Infectious Diseases AI165519NIAID NIH HHS R01 AI127472NIAID NIH HHS R01 AI165519
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anti-Bacterial AgentsBacterial ProteinsDNA-Directed RNA PolymerasesDrug Resistance, BacterialEnterococcus faeciumMutationRifampinAllelesGram-Positive Bacterial InfectionsHumansMicrobial Sensitivity TestsAnti-Bacterial AgentsBacterial ProteinsDNA-Directed RNA PolymerasesRifampinRNA polymerase beta subunitantibiotic resistanceDNA-directed RNA polymeraseEnterococcus faeciumfunctional genomicsRpoBtranscriptomics

Identifiers

PMID41342532
PMCPMC12724266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.