ArticleTransfusion2026
Suppression of RBC alloimmunization and regulation of CD4
Article in Transfusion, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Suppression of RBC alloimmunization and regulation of CD4Transfusion · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundActivation of complement protein C3 generally enhances antibody responses and C3-null mice have decreased antibody-based immunity. Mener et al. have reported a paradoxical suppressor function for C3 in alloimmunization to transfused RBCs as alloantibodies are increased in C3-null mice. Moreover, C3 regulated the CD4
methodsWe used CRISPR/Cas9 to generate a new C3-null mouse (C3Cr-KO) directly in B6 mice lacking any 129 genetic elements. B6 and C3Cr-KO mice were transfused with KEL-K2
resultsIdentical to the findings of Mener et al., alloimmunization was increased in C3Cr-KO mice compared to wild-type B6 mice and CD4
conclusionsThe current findings eliminate a common confounder present in murine knockout systems that has caused erroneous conclusions in other settings. Both the conclusion that the presence of the C3 gene decreases RBC alloimmunization and regulates CD4
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Registered trials
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