Evidence map›Paper›PMID 41342351›Full record

ArticleAmerican journal of epidemiology2026

A preconception cohort study of historical mortgage lending discrimination and present-day fecundability.

Sharonda M Lovett, Lauren A Wise, Andrea S Richardson, Erin J Campbell, Kaylin A Vrkljan, Kipruto Kirwa, Amelia K Wesselink, Kenneth J Rothman, Mary D Willis

Abstract read
In one paragraph

Article in American journal of epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Racialized economic segregation in relation to fecundability in a preconception cohort study.Journal of urban health : bulletin of the New York Academy of Medicine · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sharonda M LovettDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, United States.ORCID 0000-0002-5840-6404
Lauren A WiseDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, United States.ORCID 0000-0003-2138-3752
Andrea S RichardsonDepartment of Behavioral and Policy Sciences, RAND Corporation, Pittsburgh, PA, United States.ORCID 0000-0001-6894-8226
Erin J CampbellDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, United States.ORCID 0000-0002-4884-1621
Kaylin A VrkljanDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, United States.ORCID 0009-0000-8645-6161
Kipruto KirwaDepartment of Environmental Health, Boston University School of Public Health, Boston, MA, United States.
Amelia K WesselinkDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, United States.ORCID 0000-0002-3929-4451
Kenneth J RothmanDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, United States.ORCID 0000-0003-2398-1705
Mary D WillisDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, United States.ORCID 0000-0002-0247-7983

Funding

An internet-based preconception cohort study in North America and DenmarkR01HD086742 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI LAUREN A WISE · 2016 to 2026
$6.7M
Impacts of Racial Disparities Mortgage Lending Practices on ObesityR01HL155187 · NHLBI · RAND CORPORATION · PI Andrea Richardson · 2022 to 2026
$3.2M
A Preconception Cohort Study on Oil and Gas Development, Fertility, and PregnancyDP5OD033415 · OD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WILLIS, MARY D · 2022 to 2025
$2.2M
NHLBI NIH HHS R01 HL155187NICHD NIH HHS R01 HD086742NIH HHS DP5 OD033415NIH/NHLBI R01-HL155187NIH/NICHD R01-HD08,6742NIH/OD DP5-OD033415S1
6 · The paper itself

Abstract

We estimated the association between redlining, a historic racist practice of mortgage lending discrimination, and fecundability, the per-cycle probability of conception. We analyzed data from 1901 U.S. female participants aged 21-45 years in Pregnancy Study Online (PRESTO; 2013-2023), a prospective preconception cohort study. Participants completed self-administered questionnaires at baseline and every 2 months until conception or 12 months, whichever came first. Using participants' baseline residential addresses, we linked to neighborhoods graded by the U.S. Home Owners' Loan Corporation (HOLC) during the 1930s for perceived riskiness of mortgage lending: A + B (best or still desirable), C (definitely declining), and D (hazardous; ie, redlined). We used proportional probabilities regression models to estimate fecundability ratios (FRs) and 95% CIs, adjusting for age, calendar year of enrollment, and geographic region of residence. Most participants resided in neighborhoods with riskier grades: 47.1% grade C and 21.7% grade D. Compared with neighborhoods graded A + B, FRs were 0.91 (95% CI, 0.81-1.03) and 0.86 (95% CI, 0.74-1.00) for neighborhoods graded C and D, respectively. In this preconception cohort study, current residence in a historically redlined or declining neighborhood was associated with a moderate decrease in fecundability.

Indexed as

FertilityHousingAdultFemaleHumansMiddle AgedPregnancyProspective StudiesUnited StatesYoung Adultfecundabilityfertilityneighborhood characteristicsredliningstructural racism

Identifiers

PMID41342351
PMCPMC13055443

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.