ArticleJournal of cutaneous pathology2026
What the Eyelid Can Tell You: The Unexpected Initial Presentation of De Novo Stage IV Breast Carcinoma.
Article in Journal of cutaneous pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- What the Eyelid Can Tell You: The Unexpected Initial Presentation of De Novo Stage IV Breast Carcinoma.Journal of cutaneous pathology · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 66-year-old female presented with seven months of progressive right upper eyelid (RUL) drooping and thickening of her right lower eyelid (RLL). MRI revealed soft tissue enhancement of the RUL and RLL pre-septal planes without posterior extension. Biopsy revealed poorly cohesive carcinoma infiltrating in a linear architectural pattern with foci of signet ring cell forms. Positivity for mucicarmine, keratin CAM5.2, CK7, GATA3, BRST-2, mammaglobin, and ER supported a metastatic breast carcinoma to the eyelid without a previously known primary site. E-cadherin and p120-catenin membranous staining was suggestive of a ductal breast carcinoma with lobular features as the initial presentation of de novo stage IV breast carcinoma. Subsequent follow-up with oncology revealed a palpable right breast mass with associated lymphadenopathy. Estrogen receptor PET scan showed disease in the right breast, right axilla, left cervical nodes, calvarium, and orbit. Biopsy of the right breast lesion confirmed a carcinoma histopathologically and immunohistochemically identical to that found in the eyelid biopsy. This case's histopathological features of invasive ductal breast carcinoma masquerading as invasive lobular carcinoma exemplify the challenging complexity of mixed disease.
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Registered trials
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