ArticleCirculation research2026
Endothelial ADAR1 Deficit Induces the NOCT-IRF7 Axis in Pulmonary Hypertension.
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Article in Circulation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Global knockout of melanoma differentiation-associated protein 5 protects mice from chronic hypoxia/SU5416-induced pulmonary hypertension.American journal of physiology. Lung cellular and molecular physiology · 2026Article
- Adenosine-to-Inosine (A-to-I) RNA Editing by ADAR1 to Control RNA Sensing in Cardiovascular Disease.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Circadian control of immune homeostasis in cardiovascular health and disease.Frontiers in immunology · 2026Review
- Neonatal pulmonary vascular remodeling induced by increased blood flow is associated with an antiviral-like immune signature.Frontiers in immunology · 2026Article
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Authors and funding
28 authors.
Chen-Shan Chen Woodcock *Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute (C.C.W., Y.Y.T., Y.T., S.O., R.H., S.J., B.W., Y.A.A., T.V.K., S.Y.C.).ORCID 0000-0003-4291-1788
Giovanni Maroli *Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Institute for Lung Health (ILH), Cardio-Pulmonary Institute (CPI), Member of the German Center for Lung Research (DZL), Giessen, Germany (G.M., S.S.P.).ORCID 0000-0001-8245-5348
Hyunbum Kim *Division of Pulmonary Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA (H.K., Y.K., K.Y.).ORCID 0000-0002-7193-0278
Yi Yin Tai *Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute (C.C.W., Y.Y.T., Y.T., S.O., R.H., S.J., B.W., Y.A.A., T.V.K., S.Y.C.).
Ying Tang *Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute (C.C.W., Y.Y.T., Y.T., S.O., R.H., S.J., B.W., Y.A.A., T.V.K., S.Y.C.).
Satoshi OkawaCenter for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute (C.C.W., Y.Y.T., Y.T., S.O., R.H., S.J., B.W., Y.A.A., T.V.K., S.Y.C.).
Rami HomsiCenter for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute (C.C.W., Y.Y.T., Y.T., S.O., R.H., S.J., B.W., Y.A.A., T.V.K., S.Y.C.).
Yunhye KimDivision of Pulmonary Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA (H.K., Y.K., K.Y.).ORCID 0009-0002-1804-571X
Shu-Ting ChoDepartment of Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA (S.O., S.C.).
Siyi JiangCenter for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute (C.C.W., Y.Y.T., Y.T., S.O., R.H., S.J., B.W., Y.A.A., T.V.K., S.Y.C.).ORCID 0000-0002-5481-2771
Caroline ChauvetUniversité Côte d'Azur, CNRS, IPMC, Valbonne, France (C.C., T.B.).
Bing WangCenter for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute (C.C.W., Y.Y.T., Y.T., S.O., R.H., S.J., B.W., Y.A.A., T.V.K., S.Y.C.).ORCID 0000-0002-5185-3500
Yassmin Al AarajCenter for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute (C.C.W., Y.Y.T., Y.T., S.O., R.H., S.J., B.W., Y.A.A., T.V.K., S.Y.C.).
Robert LafyatisDivision of Rheumatology, Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA (R.L.).ORCID 0000-0002-9398-5034
Rajan SaggarDivision of Pulmonary, Critical Care, Sleep Medicine, Clinical Immunology and Allergy, David Geffen School of Medicine at UCLA, Los Angeles, CA (R.S.).
John SembratDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh, PA (J.S., S.M.N.).ORCID 0000-0003-4108-803X
Qingde WangDepartment of Surgery, University of Pittsburgh School of Medicine, PA (Q.W.).
Qin LiDepartment of Genetics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA (Q.L.).ORCID 0000-0002-8948-2717
Andrea L FrumpDivision of Pulmonary, Critical Care, Sleep and Occupational Medicine, Indiana University School of Medicine, Indianapolis, IN (A.L.F.).ORCID 0000-0002-5972-5079
Tim LahmDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, CO (C.C.W., T.L., A.L.M.).
Alexandra L McCubbreyDivision of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, National Jewish Health, Denver, CO (C.C.W., T.L., A.L.M.).ORCID 0000-0002-2049-9609
Tatiana V KudryashovaCenter for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute (C.C.W., Y.Y.T., Y.T., S.O., R.H., S.J., B.W., Y.A.A., T.V.K., S.Y.C.).ORCID 0000-0002-2843-5554
Elena A GoncharovaLung Center, Division of Pulmonary, Critical Care and Sleep Medicine, University of California, Davis School of Medicine, Sacramento, CA (E.A.G.).ORCID 0000-0001-7118-6752
Seyed Mehdi NouraieDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh, PA (J.S., S.M.N.).ORCID 0000-0001-7465-0581
Thomas BerteroUniversité Côte d'Azur, CNRS, IPMC, Valbonne, France (C.C., T.B.).ORCID 0000-0002-4801-9902
Ke Yuan *Division of Pulmonary Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA (H.K., Y.K., K.Y.).ORCID 0000-0001-8085-5452
Soni S Pullamsetti *Department of Internal Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Institute for Lung Health (ILH), Cardio-Pulmonary Institute (CPI), Member of the German Center for Lung Research (DZL), Giessen, Germany (G.M., S.S.P.).ORCID 0000-0003-0440-8831
Stephen Y Chan *Center for Pulmonary Vascular Biology and Medicine, Pittsburgh Heart, Lung, and Blood Vascular Medicine Institute (C.C.W., Y.Y.T., Y.T., S.O., R.H., S.J., B.W., Y.A.A., T.V.K., S.Y.C.).ORCID 0000-0002-9520-7527
Funding
Defining the Complex Biology of the miR-130/301 Family in Pulmonary HypertensionR01HL124021 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHAN, STEPHEN Y · 2014 to 2025
$4.9MMechanisms of Right Ventricle Adaptation to Pulmonary HypertensionR01HL144727 · NHLBI · NATIONAL JEWISH HEALTH · PI Tim Lahm · 2019 to 2026
$4.7MIron-Sulfur Deficiency as a Critical Pathogenic Cause of Pulmonary HypertensionR01HL122596 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHAN, STEPHEN Y · 2015 to 2024
$4.5MThe emerging role of apelin, RAAS, and ACE2 crosstalk in pulmonary hypertensionR01HL164791 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI Andrea Lee Frump · 2022 to 2026
$3.8MGenetic and hypoxic control of a lncRNA axis orchestrates endothelial reprogramming in pulmonary hypertensionR01HL151228 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Stephen Y Chan · 2023 to 2026
$2.8MHIPK2 signaling in Pulmonary Arterial HypertensionR01HL166932 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Tatiana V Kudryashova · 2023 to 2026
$1.6MRNA editing controls pulmonary endothelial pathophenotypes in pulmonary hypertensionR00HL161320 · NHLBI · NATIONAL JEWISH HEALTH · PI Chen-Shan Julia Woodcock · 2024 to 2026
$747kRNA editing controls pulmonary endothelial pathophenotypes in pulmonary hypertensionK99HL161320 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WOODCOCK, CHEN-SHAN JULIA · 2022 to 2023
$212kNHLBI NIH HHS K99 HL161320NHLBI NIH HHS R00 HL161320NHLBI NIH HHS R01 HL122596NHLBI NIH HHS R01 HL124021NHLBI NIH HHS R01 HL144727NHLBI NIH HHS R01 HL151228NHLBI NIH HHS R01 HL164791NHLBI NIH HHS R01 HL166932
Abstract
backgroundEarly apoptosis of pulmonary artery endothelial cells (PAECs) is a driver of vascular remodeling and pulmonary hypertension (PH), but its regulation is poorly defined. Adenosine deaminase acting on RNA 1 (ADAR1, gene name
methodsADAR1 or Nocturnin (NOCT) expression and A-to-I RNA editing levels were evaluated in human PAH lungs by immunofluorescent staining and single cell RNA sequencing, respectively. Mice carrying a human missense
resultsADAR1 expression was downregulated in the pulmonary vascular endothelium and in lung tissue of human and mouse PH. Global A-to-I RNA editing was decreased in lungs from PAH patients and hypoxic PH mice. In vitro, hypoxia, a PH trigger, downregulated ADAR1 in PAECs. Circadian gene
conclusionsHypoxia-induced ADAR1 deficiency upregulates
Indexed as
Adenosine DeaminaseEndothelial CellsHypertension, PulmonaryRNA-Binding ProteinsAnimalsApoptosisCells, CulturedDisease Models, AnimalHumansHypoxiaMaleMiceMice, Inbred C57BLMice, TransgenicPulmonary ArteryRNA EditingADAR1 protein, mouseADAR protein, humanAdenosine DeaminaseRNA-Binding Proteinsapoptosisendothelial cellsinterferonnocturninpulmonary artery
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