Evidence map›Paper›PMID 41342134›Full record

ArticleCirculation research2026

L-Type Ca

Eleonora Torre, Mélanie Faure, Isabelle Bidaud, Matthias Baudot, Marvin Gaillardon, Walma Pereira de Vasconcelos, Sihame Laarioui, Leïla Talssi, Birgit Engeland, Steven Reiken and 9 more

Abstract read
In one paragraph

Article in Circulation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Eleonora Torre *Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, France (E.T., M.F., I.B., M.B., M.G., W.P.d.V., S.L., L.T., P.M., M.E.M.).ORCID 0000-0003-1822-8495
Mélanie Faure *Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, France (E.T., M.F., I.B., M.B., M.G., W.P.d.V., S.L., L.T., P.M., M.E.M.).
Isabelle Bidaud *Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, France (E.T., M.F., I.B., M.B., M.G., W.P.d.V., S.L., L.T., P.M., M.E.M.).ORCID 0000-0002-1812-1447
Matthias BaudotInstitut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, France (E.T., M.F., I.B., M.B., M.G., W.P.d.V., S.L., L.T., P.M., M.E.M.).ORCID 0000-0002-8725-3048
Marvin GaillardonInstitut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, France (E.T., M.F., I.B., M.B., M.G., W.P.d.V., S.L., L.T., P.M., M.E.M.).
Walma Pereira de VasconcelosInstitut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, France (E.T., M.F., I.B., M.B., M.G., W.P.d.V., S.L., L.T., P.M., M.E.M.).ORCID 0009-0000-2471-8445
Sihame LaariouiInstitut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, France (E.T., M.F., I.B., M.B., M.G., W.P.d.V., S.L., L.T., P.M., M.E.M.).ORCID 0009-0009-4852-371X
Leïla TalssiInstitut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, France (E.T., M.F., I.B., M.B., M.G., W.P.d.V., S.L., L.T., P.M., M.E.M.).
Birgit EngelandInstitute for Molecular and Behavioral Neuroscience, University Hospital Cologne, Germany (B.E., D.I.).
Steven ReikenDepartment of Physiology and Cellular Biophysics (S.R., A.R.M.), Columbia University Vagelos College of Physicians and Surgeons, New York, NY.ORCID 0000-0002-5807-3574
Andrea SaponaroDepartment of Pharmacological and Biomolecular Sciences (A.S.), University of Milan, Italy.ORCID 0000-0001-5035-5174
Bi-Xing ChenDivision of Cardiology, Department of Medicine (B.-X.C., S.O.M.), Columbia University Vagelos College of Physicians and Surgeons, New York, NY.
Anna MoroniDepartment of Biosciences (A.M.), University of Milan, Italy.ORCID 0000-0002-1860-406X
Alicia D'SouzaNational Heart and Lung Institute, Imperial College London, United Kingdom (A.D.).ORCID 0000-0002-9700-5523
Dirk IsbrandtInstitute for Molecular and Behavioral Neuroscience, University Hospital Cologne, Germany (B.E., D.I.).ORCID 0000-0002-4720-1016
Andrew R MarksDepartment of Physiology and Cellular Biophysics (S.R., A.R.M.), Columbia University Vagelos College of Physicians and Surgeons, New York, NY.ORCID 0000-0002-8057-1502
Steven O MarxDivision of Cardiology, Department of Medicine (B.-X.C., S.O.M.), Columbia University Vagelos College of Physicians and Surgeons, New York, NY.ORCID 0000-0002-0577-6030
Pietro MesircaInstitut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, France (E.T., M.F., I.B., M.B., M.G., W.P.d.V., S.L., L.T., P.M., M.E.M.).ORCID 0000-0002-9538-3096
Matteo E MangoniInstitut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, France (E.T., M.F., I.B., M.B., M.G., W.P.d.V., S.L., L.T., P.M., M.E.M.).ORCID 0000-0002-8892-3373

Funding

Phosphorylation-dependent regulation of calcium channels by macromolecular complexesR01HL146149 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Steven O Marx, Geoffrey S Pitt · 2019 to 2026
$5.0M
Investigating Cardiac Ion Channels by Novel MethodsR01HL155377 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Steven O Marx · 2021 to 2026
$3.8M
Investigation of calcium modulation in cardiomyocytes by novel methodsR01HL113136 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MARX, STEVEN O, PITT, GEOFFREY S · 2013 to 2016
$2.2M
NHLBI NIH HHS R01 HL113136NHLBI NIH HHS R01 HL146149NHLBI NIH HHS R01 HL155377
6 · The paper itself

Abstract

backgroundThe ionic mechanism by which catecholamines increase the heart rate is incompletely understood. In this study, we have assessed the roles of sinoatrial node L-type Ca

methodsWe studied β-adrenergic regulation of heart rate and sinoatrial pacemaker activity in mice lacking Ca

resultsMutant mice with knockout of Ca

conclusionsPKA phosphorylation of Rad, which disinhibits Ca

Indexed as

Calcium Channels, L-TypeCatecholaminesHeart RateHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsSinoatrial NodeAdrenergic beta-AgonistsAnimalsBiological ClocksCalcium Channel BlockersCyclic AMPElectrocardiographyFemaleGene Expression RegulationIsolated Heart PreparationMaleMiceAdrenergic beta-AgonistsCACNA1C protein, mouseCacna1d protein, mouseCalcium Channel BlockersCalcium Channels, L-TypeCatecholaminesCyclic AMPHcn4 protein, mouseHyperpolarization-Activated Cyclic Nucleotide-Gated Channelsras ProteinsReceptors, Adrenergic, betaRrad protein, mouseSympathomimeticscatecholaminesheart ratephosphorylationsinoatrial nodesympathomimetics

Identifiers

PMID41342134
PMCPMC12757128

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.