Evidence map›Paper›PMID 41342124›Full record

ArticleCirculation research2026

Human Hearts Intrinsically Increase Cardiomyocyte Mitosis After Myocardial Infarction.

Robert D Hume, Jessica Warwick, Woo Jun Shim, Cassandra Malecki, Mengbo Li, Lakshay Seth, Dylan Harney, Julien Dagher, Trina Lum, Geraldine Tierney and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Robert D HumeSchool of Medical Sciences, Faculty of Medicine and Health (R.D.H., J.W., C.M., L.S., D.H., E.S., X.W., L.N., L.C., A.L.F., M.L., S.L.), University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0003-3694-9333
Jessica WarwickSchool of Medical Sciences, Faculty of Medicine and Health (R.D.H., J.W., C.M., L.S., D.H., E.S., X.W., L.N., L.C., A.L.F., M.L., S.L.), University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0003-2519-5767
Woo Jun ShimInstitute for Molecular Bioscience, University of Queensland, St Lucia, Queensland, Australia (W.J.S., N.J.P.).ORCID 0000-0001-9446-7821
Cassandra MaleckiSchool of Medical Sciences, Faculty of Medicine and Health (R.D.H., J.W., C.M., L.S., D.H., E.S., X.W., L.N., L.C., A.L.F., M.L., S.L.), University of Sydney, Sydney, New South Wales, Australia.
Mengbo LiWalter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia (M. Li).ORCID 0000-0002-9666-5810
Lakshay SethSchool of Medical Sciences, Faculty of Medicine and Health (R.D.H., J.W., C.M., L.S., D.H., E.S., X.W., L.N., L.C., A.L.F., M.L., S.L.), University of Sydney, Sydney, New South Wales, Australia.
Dylan HarneySchool of Medical Sciences, Faculty of Medicine and Health (R.D.H., J.W., C.M., L.S., D.H., E.S., X.W., L.N., L.C., A.L.F., M.L., S.L.), University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-1148-5838
Julien DagherTissue Pathology and Diagnostic Oncology, NSW Health Pathology (J.D., T.L., G.T., W.C.), Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
Trina LumTissue Pathology and Diagnostic Oncology, NSW Health Pathology (J.D., T.L., G.T., W.C.), Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
Geraldine TierneyTissue Pathology and Diagnostic Oncology, NSW Health Pathology (J.D., T.L., G.T., W.C.), Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.
Wendy CooperTissue Pathology and Diagnostic Oncology, NSW Health Pathology (J.D., T.L., G.T., W.C.), Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.ORCID 0000-0001-5418-4229
Eugene SlaughterSchool of Medical Sciences, Faculty of Medicine and Health (R.D.H., J.W., C.M., L.S., D.H., E.S., X.W., L.N., L.C., A.L.F., M.L., S.L.), University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0003-3535-6990
Xiaosuo WangSchool of Medical Sciences, Faculty of Medicine and Health (R.D.H., J.W., C.M., L.S., D.H., E.S., X.W., L.N., L.C., A.L.F., M.L., S.L.), University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0003-3487-4614
Lisa NguyenSchool of Medical Sciences, Faculty of Medicine and Health (R.D.H., J.W., C.M., L.S., D.H., E.S., X.W., L.N., L.C., A.L.F., M.L., S.L.), University of Sydney, Sydney, New South Wales, Australia.
Louise ColeSchool of Medical Sciences, Faculty of Medicine and Health (R.D.H., J.W., C.M., L.S., D.H., E.S., X.W., L.N., L.C., A.L.F., M.L., S.L.), University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0001-9206-9272
James EdelmanDepartment of Cardiothoracic Surgery (J.E., P.B.), Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.ORCID 0009-0007-6069-2474
Fairooj N RashidSydney Medical School (F.N.R., C.H., A.G., J.J.H.C., P.B.), University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0001-8319-7117
Callum HoulahanSydney Medical School (F.N.R., C.H., A.G., J.J.H.C., P.B.), University of Sydney, Sydney, New South Wales, Australia.ORCID 0009-0008-7422-8282
Antony GaoSydney Medical School (F.N.R., C.H., A.G., J.J.H.C., P.B.), University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0003-2628-1376
Angela L FergusonSchool of Medical Sciences, Faculty of Medicine and Health (R.D.H., J.W., C.M., L.S., D.H., E.S., X.W., L.N., L.C., A.L.F., M.L., S.L.), University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0001-5974-0423
James J H ChongSydney Medical School (F.N.R., C.H., A.G., J.J.H.C., P.B.), University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-5201-4856
Mark LaranceSchool of Medical Sciences, Faculty of Medicine and Health (R.D.H., J.W., C.M., L.S., D.H., E.S., X.W., L.N., L.C., A.L.F., M.L., S.L.), University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-8579-2267
John F O'SullivanThe Charles Perkins Centre (R.D.H., J.W., C.M., L.S., D.H., A.L.F., M.L., J.F.O., P.B., S.L.), University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0001-8016-5128
Nathan J PalpantInstitute for Molecular Bioscience, University of Queensland, St Lucia, Queensland, Australia (W.J.S., N.J.P.).ORCID 0000-0002-9334-8107
Paul BannonThe Charles Perkins Centre (R.D.H., J.W., C.M., L.S., D.H., A.L.F., M.L., J.F.O., P.B., S.L.), University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-3117-7250
Sean LalSchool of Medical Sciences, Faculty of Medicine and Health (R.D.H., J.W., C.M., L.S., D.H., E.S., X.W., L.N., L.C., A.L.F., M.L., S.L.), University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0002-5841-560X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMyocardial infarction (MI) is a leading cause of death worldwide and can eliminate up to a third of the cardiomyocytes within the human heart. Although cardiomyocytes undergo mitosis during early development, most cardiomyocytes cease cell cycling soon after birth. In contrast, rodent MI models have shown that cardiomyocytes increase mitosis in response to ischemia; however, this has not been shown in humans.

methodsUsing a unique premortem post-MI human heart, immunostaining, bulk RNA sequencing, proteomics, metabolomics, single-nucleus RNA sequencing and a novel post-MI human biopsy method, we investigated human cardiomyocyte mitosis post-MI.

resultsWe show that adult human cardiomyocytes exhibit increased mitosis and cytokinesis in response to ischemia.

conclusionsFuture development of therapeutics to enhance this intrinsic mitotic potential could lead to new treatments that reverse heart failure via cardiac regeneration.

Indexed as

MitosisMyocardial InfarctionMyocytes, CardiacCytokinesisFemaleHumansMaleMiddle AgedMyocardiumheartischemiamitosismyocardial infarctionmyocytes, cardiacregeneration

Identifiers

PMID41342124
PMCPMC12922688

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.