ArticleKidney medicine2025
Coronary Artery Disease and Intradialytic Myocardial Ischemia in Hemodialysis: An Exploratory Study Using Intradialytic Imaging.
Article in Kidney medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rationale & Objective: Recurrent segmental myocardial ischemia (myocardial stunning) is a well-recognized consequence of hemodialysis leading to fixed contractile deficits and increased morbidity and cardiac mortality. Although epicardial coronary artery disease (CAD) is not a prerequisite, hemodialysis patients commonly have significant arterial plaque burden, and the interaction with established CAD and hemodialysis-induced myocardial ischemic injury is currently unknown. Study Design: A single-center cross-sectional study. Setting & Participants: Thirteen patients on maintenance hemodialysis (London, Ontario, and Canada). Exposure: The presence of significant coronary stenoses as assessed using coronary computed tomography (CT) angiography. Outcomes: Principal aim was to identify changes in myocardial perfusion and stunning as assessed by CT and echocardiography, respectively. Analytical Approach: We used CT angiography with intradialytic CT perfusion and echocardiography to evaluate perfusion and ventricular contractile response during dialysis in patients with and without CAD. Coronary artery images were acquired before dialysis (baseline). The CT perfusion scans were conducted at baseline, peak-dialysis stress, and 30 minutes after dialysis to quantify global and segmental perfusion of the left ventricular myocardium. At each timepoint, segmental myocardial stunning was identified as intradialytic development of regional wall motion abnormalities using longitudinal strain analysis from 2D echocardiograms. Results: Among 13 participants, 3 were identified with asymptomatic CAD. Among the 10 participants with no identifiable CAD, there was a decrease in global myocardial perfusion from baseline to peak dialysis and a recovery to baseline level after dialysis. In asymptomatic CAD participants, the number of myocardial segments experiencing regional wall motion abnormalities was elevated at peak and after dialysis. No significant intradialytic changes in global myocardial perfusion were observed, but the presence of CAD showed additive effects on segmental perfusion and contractile response to HD. Limitations: This study was an exploratory study with a small sample size. Conclusions: This study demonstrated hemodialysis-induced circulatory stress, by a reduction in perfusion and development of myocardial stunning in the absence of CAD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.