ArticleKidney medicine2025
Insights into Geographic Patterns, Urban-Rural Contrasts, and Health Care Disparities in Glomerular Disease Incidence in a Canadian Province.
Article in Kidney medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rationale & Objective: Glomerular diseases (GDs) are a group of immune-mediated or genetic diseases that involve the filtering units of the kidneys, or glomeruli. Using centralized provincial kidney pathology records and census data, we aimed to examine the incidence and temporal trend of GDs in Saskatchewan, Canada and understand rural/urban differences in GD distribution. Study Design: Population-based epidemiologic study. Setting & Participants: All adult patients who underwent kidney biopsies in Saskatchewan, Canada, from 2002-2018. Exposures or Predictors: Biopsy diagnosis, 3-digit postal codes, laboratory parameters, dialysis initiation dates, and mortality data. Outcomes: Incidence of primary GD, dialysis initiation, and all-cause mortality. Analytical Approach: Regional variations in GD were analyzed using SaTScan v10.1.3 software. Incidence trends, rural/urban differences, and geospatial clustering were evaluated. Ethics approval was obtained from the provincial research and ethics board. Results: A total of 1,372 of 3,509 kidney biopsies met the inclusion criteria. GD incidence increased from 4.6 to 13.6 per 100,000 persons from 2002 to 2018 ( Limitations: Biopsies were dependent on the threshold of the ordering physician. Likely, frail and elderly patients and patients with early onset glomerulonephritis, late presentations, and higher bleeding risk were not biopsied, which led to an underrepresentation of these groups. Conclusions: The incidence and relative burden of GDs have increased over time in Saskatchewan, with notable rural/urban differences. We identified a geographic cluster for lupus nephropathy encompassing rural and urban areas. Patients in rural and remote areas had higher dialysis transition rates, and mortality rates were relatively higher in urban areas. Addressing and understanding the multifaceted factors driving these disparities are essential steps toward easing the burden of GDs on impacted communities.
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