Evidence map›Paper›PMID 41341984›Full record

ArticleJMIR neurotechnology2023

A Semantic Relatedness Model for the Automatic Cluster Analysis of Phonematic and Semantic Verbal Fluency Tasks Performed by People With Parkinson Disease: Prospective Multicenter Study.

Tom Hähnel, Tim Feige, Julia Kunze, Andrea Epler, Anika Frank, Jonas Bendig, Nils Schnalke, Martin Wolz, Peter Themann, Björn Falkenburger

Abstract read
In one paragraph

Article in JMIR neurotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tom HähnelDepartment of Neurology University Hospital and Faculty of Medicine Carl Gustav Carus Technische Universität Dresden Dresden Germany.ORCID https://orcid.org/0000-0002-4254-2399
Tim FeigeGerman Center for Neurodegenerative Diseases (DZNE) Dresden Germany.ORCID https://orcid.org/0009-0004-3377-3234
Julia KunzeDepartment of Neurology University Hospital and Faculty of Medicine Carl Gustav Carus Technische Universität Dresden Dresden Germany.ORCID https://orcid.org/0009-0000-1416-4872
Andrea EplerDepartment of Neurology University Hospital and Faculty of Medicine Carl Gustav Carus Technische Universität Dresden Dresden Germany.ORCID https://orcid.org/0000-0002-6089-7206
Anika FrankDepartment of Neurology University Hospital and Faculty of Medicine Carl Gustav Carus Technische Universität Dresden Dresden Germany.ORCID https://orcid.org/0000-0003-4675-2534
Jonas BendigDepartment of Neurology University Hospital and Faculty of Medicine Carl Gustav Carus Technische Universität Dresden Dresden Germany.ORCID https://orcid.org/0000-0001-9237-535X
Nils SchnalkeDepartment of Neurology University Hospital and Faculty of Medicine Carl Gustav Carus Technische Universität Dresden Dresden Germany.ORCID https://orcid.org/0000-0002-0870-8105
Martin WolzDepartment of Neurology and Geriatrics Elblandklinikum Meißen Meißen Germany.ORCID https://orcid.org/0000-0003-0676-8611
Peter ThemannDepartment of Neurology Klinik am Tharandter Wald Halsbrücke Germany.ORCID https://orcid.org/0000-0003-2433-7831
Björn FalkenburgerDepartment of Neurology University Hospital and Faculty of Medicine Carl Gustav Carus Technische Universität Dresden Dresden Germany.ORCID https://orcid.org/0000-0002-2387-526X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Phonematic and semantic verbal fluency tasks (VFTs) are widely used to capture cognitive deficits in people with neurodegenerative diseases. Counting the total number of words produced within a given time frame constitutes the most commonly used analysis for VFTs. The analysis of semantic and phonematic word clusters can provide additional information about frontal and temporal cognitive functions. Traditionally, clusters in the semantic VFT are identified using fixed word lists, which need to be created manually, lack standardization, and are language specific. Furthermore, it is not possible to identify semantic clusters in the phonematic VFT using this technique. Objective: The objective of this study was to develop a method for the automated analysis of semantically related word clusters for semantic and phonematic VFTs. Furthermore, we aimed to explore the cognitive domains captured by this analysis for people with Parkinson disease (PD). Methods: People with PD performed tablet-based semantic (51/85, 60%) and phonematic (69/85, 81%) VFTs. For both tasks, semantic word clusters were determined using a semantic relatedness model based on a neural network trained on the Wikipedia (Wikimedia Foundation) text corpus. The cluster characteristics derived from this model were compared with those derived from traditional evaluation methods of VFTs and a set of neuropsychological parameters. Results: For the semantic VFT, the cluster characteristics obtained through automated analyses showed good correlations with the cluster characteristics obtained through the traditional method. Cluster characteristics from automated analyses of phonematic and semantic VFTs correlated with the overall cognitive function reported by the Montreal Cognitive Assessment, executive function reported by the Frontal Assessment Battery and the Trail Making Test, and language function reported by the Boston Naming Test. Conclusions: Our study demonstrated the feasibility of standardized automated cluster analyses of VFTs using semantic relatedness models. These models do not require manually creating and updating categorized word lists and, therefore, can be easily and objectively implemented in different languages, potentially allowing comparison of results across different languages. Furthermore, this method provides information about semantic clusters in phonematic VFTs, which cannot be obtained from traditional methods. Hence, this method could provide easily accessible digital biomarkers for executive and language functions in people with PD.

Indexed as

cognitionexecutive functionlanguage functionmild cognitive impairmentParkinson diseaseParkinson disease dementiasemantic clusterssemantic relatednessverbal fluency tasks

Identifiers

PMID41341984
PMCPMC12671300

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.