ArticleFrontiers in cellular and infection microbiology2025
Plasmid-associated clonal expansion drives department-preference transmission of carbapenem-resistant
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Genomic dynamics of antimicrobial resistance transmission between bacteria from intensive care unit surfaces and from critically ill patients.Critical care (London, England) · 2026Article
- Genomic Epidemiology and Plasmid-Mediated Dissemination of Carbapenem-ResistantInfection and drug resistance · 2026Article
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14 authors.
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Abstract
Background: The drivers of expanding carbapenem-resistant Methods: We conducted a comprehensive analysis in a tertiary teaching hospital (September 2017-December 2019) by clinical data evaluation, antimicrobial susceptibility testing, and genome sequencing to characterize sequence types (STs), resistance and virulence genes, and plasmid profiles. Results: CRKP isolation rate increased from 3.6% to 17.2% during 2017-2019. Of 140 cases, 31.43% occurred in the Department of Hepatobiliary Surgery and 31 (22.14%) in the ICU, with a predominance among elderly male patients. Surgery and interventional therapy were performed in 50.7% and 25.7% of cases, respectively. Among 23 STs identified, ST11 (72.1%) was the most prevalent and exhibited high rate of multidrug resistance, commonly associated with narrow-spectrum β-lactamases-coding genes (highest in 110/140), Conclusions: Department-specific plasmid combinations considerably increased CRKP infection and multidrug resistance rates. Surgical and interventional therapies were vital factors contributing to CRKP infections, especially in elderly male patients.
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