ReviewIntractable & rare diseases research2025
A scoping review of dietary interventions to treat obesity among Prader-Willi syndrome individuals.
Review in Intractable & rare diseases research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prader-Willi syndrome (PWS) is a genetic disorder resulting from the absence of paternal 15q11-q13 alleles and is clinically characterised by pathological obesity, delayed satiety, hyperphagia, decreased muscle mass, and increased fat mass. Dietary management constitutes a key component in the prevention and treatment of obesity in individuals with PWS. This scoping study aimed to identify dietary interventions available for treating obesity among PWS individuals. A systematic search using the six stages of the scoping review methodology proposed by Arksey and O'Malley was conducted across four databases: PubMed, Scopus, EBSCOhost, and Cochrane Library. The inclusion criteria were full-text research articles published in English between 2017 and 2023, involving human participants with PWS, and reporting on dietary interventions for obesity management. Out of 100 articles retrieved, five studies were identified. Two studies described multidisciplinary programs integrating dietary and physical activity components, while three focused exclusively on dietary interventions. The outcomes varied by intervention and study design. Ketogenic diets and multidisciplinary programs with exercise often resulted in favourable weight and body fat reduction. However, strict diets like the modified Atkins faced adherence challenges and frequent weight regain. Multidisciplinary, supervised programs result in higher adherence and more effective weight management, with body mass index near normal. In conclusion, although research in this area remains limited, current evidence suggests that both dietary and multidisciplinary interventions have the potential to support obesity management in individuals with PWS.
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