ReviewInternational journal of nanomedicine2025
Engineered Carbon Nanotube Scaffolds for Next-Generation Tissue Engineering: Synergizing Mechanical, Electrical, and Bioactive Properties - a Review.
Review in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Nanotube-Assisted Motor Neuron and Neuromuscular Junction Stabilization in Spinal Muscular Atrophy: A Hypothesis for Adjunctive Therapy.Neurology international · 2026Review
- Advanced additive manufacturing in orthopedics: a comprehensive review of biomaterials, structural design, biological functions and clinical technology applications.RSC advances · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carbon nanotubes (CNTs) and their composites exhibit considerable potential for application in tissue engineering, owing to their unique physical, chemical, and biological properties which render them ideal candidates for constructing biological scaffolds, facilitating tissue regeneration, and enhancing cellular functions. This review systematically examines the application of CNT-based scaffolds, with a focus on their synergistic mechanical, electrical, and bioactive properties. We discuss the fundamental characteristics of CNTs, including their mechanical strength, electrical conductivity, chemical modifiability, antimicrobial activity, and the central challenge of cytotoxicity. Strategies to mitigate cytotoxicity through functionalization and composite formation are elaborated. The review probes the enhanced biocompatibility, electrical properties, and mechanical performance of CNT composites, alongside their applications in bone, neural, and cardiac tissue engineering. A specific focus is placed on CNT scaffolds functionalized with growth factors, such as vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF), highlighting their role in promoting angiogenesis and osteogenesis. Finally, we summarize the current state of the field, address existing limitations-particularly regarding cytotoxicity and long-term safety-and suggest promising directions for future research, including the integration of photothermal therapy and the need for more comprehensive in vivo studies. This review aims to provide a balanced and critical perspective on the journey of CNT-based scaffolds from laboratory innovation to clinical reality.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.