Evidence map›Paper›PMID 41341849›Full record

ArticleiScience2025

Microglial Prrc2a regulates microglia-neuron interaction in cerebellum and motor functions in mice.

Xiaoheng Li, Pin Yang, Binbin Dong, Lingling Jiang, Ruilian Xiu, Jia Guo, Shuoshuo Li, Ping Zhang, Runze Gu, Ao Li and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Xiaoheng LiThe Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing 100850, China.
Pin YangThe Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing 100850, China.
Binbin DongDepartment of Physiology and Department of Neurology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
Lingling JiangKey Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong Province Key Laboratory of Psychiatric Disorders, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.
Ruilian XiuDepartment of Neurobiology, Hebei Medical University, Shijiazhuang 050017, China.
Jia GuoKey Laboratory of Mass Spectrometry Imaging and Metabolomics, Minzu University of China, Beijing 100081, China.
Shuoshuo LiThe Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing 100850, China.
Ping ZhangLaboratory of Environment and Health, College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Runze GuCenter on Translational Neuroscience, College of Life and Environmental Science, Minzu University of China, Beijing 100081, China.
Ao LiCenter on Translational Neuroscience, College of Life and Environmental Science, Minzu University of China, Beijing 100081, China.
Jinyu ZhangThe Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing 100850, China.
Rong WuThe Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing 100850, China.
Fengchao WangNational Institute of Biological Sciences, Beijing 102206, China.
Ying ShenDepartment of Physiology and Department of Neurology of Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
Ningsheng ShaoThe Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing 100850, China.
Jinbo ChengThe Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing 100850, China.
Zengqiang YuanThe Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing 100850, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The crosstalk between microglia and neuron has been recognized as a crucial process in the development and disorders of the central nervous system. The present study probes into the role of Prrc2a-a post-transcriptional regulator that binds and stabilizes transcripts pivotal for microglial development-specifically within cerebellar microglia using a microglia-targeted conditional knockout model, identifying it as a crucial regulator of microglial function. Single-cell RNA sequencing underscored a transcriptomic shift in

Indexed as

Cell biologyMolecular biologyNeuroscience

Identifiers

PMID41341849
PMCPMC12670927

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.