ArticleFrontiers in medicine2025
Case Report: Imaging findings in sneaky subungual amelanotic melanoma.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
We report a rare case of solitary subungual malignant melanoma in a female patient who presented with a misaligned nail without accompanying pigmentary changes. The absence of typical clinical and imaging features delayed definitive diagnosis. Both magnetic resonance imaging (MRI) and ultrasound (US) initially suggested a benign lesion, favoring subungual telangiectatic granuloma. However, histopathology ultimately confirmed subungual melanoma with negative Human Melanoma Black-45 (HMB-45) immunostaining. Amelanotic melanomas are particularly prone to misdiagnosis or delayed recognition due to their lack of visible pigmentation. We present a detailed analysis of the imaging and pathological findings, highlighting specific ultrasound characteristics, with the aim of providing a valuable reference for the clinical diagnosis and management of such uncommon cases.
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