ArticleThe journal of allergy and clinical immunology. Global2026
Lymphedema in patients with X-linked severe combined immunodeficiency.
Article in The journal of allergy and clinical immunology. Global, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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8 authors.
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Abstract
Background: Objective: We present 3 IL2RG SCID cases complicated by lymphedema and discuss possible hypotheses of this rare complication. Methods: We describe 3 patients with IL2RG SCID who developed lymphedema: 2 after unconditioned cell therapy and 1 with a hypomorphic mutation who remained untreated. Clinical presentation, immunologic data, imaging, and transplant history were reviewed and compared with published data. Results: Lymphedema affected the lower limbs and varied in severity, with one case complicated by recurrent dermohypodermitis and Conclusion: Lymphedema is a rare but potentially disabling complication of IL2RG/JAK3 SCID, affecting long-term quality of life. Hypothetically, low/absent levels of innate lymphoid cells-particularly lymphoid tissue inducer cells, a subset of innate lymphoid cells-may be a contributing factor in the pathogenesis of lymphedema in IL2RG/JAK3 SCID.
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