Evidence map›Paper›PMID 41341744›Full record

ReviewChronic diseases and translational medicine2025

The Aging Gut-Brain Axis: Effects of Dietary Polyphenols and Metal Exposure.

Luqi Cao, Saurabh Kumar Jha, Neha Gupta, Xiang Chen, Renuka Soni, Luoxi Yuan, Rashi Srivastava, Zhe-Sheng Chen

Abstract readReview
In one paragraph

Review in Chronic diseases and translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Luqi CaoDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences St. John's University New York New York USA.
Saurabh Kumar JhaDepartment of Zoology, Kalindi College University of Delhi Delhi India.ORCID https://orcid.org/0000-0002-7437-0755
Neha GuptaSchool of Studies in Biotechnology Jiwaji University Gwalior Madhya Pradesh India.
Xiang ChenDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences St. John's University New York New York USA.
Renuka SoniDepartment of Biotechnology Panjab University Chandigarh India.
Luoxi YuanDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences St. John's University New York New York USA.
Rashi SrivastavaDepartment of Chemical & Biochemical Engineering Indian Institute of Technology Patna Bihar India.
Zhe-Sheng ChenDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences St. John's University New York New York USA.ORCID https://orcid.org/0000-0002-8289-097X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diet provides essential metals, which are required for the growth, development, and well-functioning of the body. Nonetheless, some natural and human activities add toxic heavy metals to the diet, consequently introducing them to our bodies, resulting in several disorders and death. The intestine, the metabolism and absorption site of metals, uptakes them through transporters, active processes, and passive processes. It harbors Enteric nervous system (ENS), connecting directly to central nervous system (CNS) and the micro-organisms acting as an endocrine organ, thus regulating the movement of metals into the host. Gut microbes mediate the uptake of essential metals and prohibit toxic metals. However, the imbalance in their concentration manifests into various neurodegenerative diseases via gut involving

Indexed as

diagnosisessential metalsgut microbiotaneurological disorderstoxic metals

Identifiers

PMID41341744
PMCPMC12670974

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.