Recurrent vaccine-strain varicella zoster virus reactivation in a child with acute lymphatic leukemia.

Antonia Leutert, Aida Zeckanovic, Michael Huber, Patrick M Meyer Sauteur, Raphael J Morscher

Abstract read

In one paragraph

Article in IDCases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Antonia LeutertDivision of Oncology, University Children's Hospital Zurich and Children's Research Center, University of Zurich, Zurich, Switzerland.

Aida ZeckanovicDivision of Oncology, University Children's Hospital Zurich and Children's Research Center, University of Zurich, Zurich, Switzerland.

Michael HuberInstitute of Medical Virology, University of Zurich, Zurich, Switzerland.

Patrick M Meyer SauteurDivision of Infectious Diseases and Hospital Epidemiology, Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.

Raphael J MorscherDivision of Oncology, University Children's Hospital Zurich and Children's Research Center, University of Zurich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This case illustrates recurrent herpes zoster (HZ) in a child with acute lymphatic leukemia. Interestingly, vaccine-strain HZ was confirmed by identifying the live-attenuated Oka vaccine strain (vOka) using metagenomic sequencing and sequence comparison at three loci that distinguish vOka from wild-type varicella zoster virus (VZV). Although vaccine-strain HZ is generally milder than HZ caused by wild-type VZV, prompt recognition and initiation of antiviral treatment is essential in immunocompromised patients, as fatal varicella due to disseminated vaccine-strain VZV has been reported in this high risk group.

Indexed as

Immune compromisedLive-attenuated vaccine reactivationOka vaccine strainVaricella zoster

Identifiers

PMID41341716

DOI10.1016/j.idcr.2025.e02422

PMCPMC12670952

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.