Evidence map›Paper›PMID 41341587›Full record

ArticleFrontiers in immunology2025

mRNA-engineered T lymphocytes secreting bispecific T cell engagers with therapeutic potential in solid tumors.

Ivana Zagorac, Ángel Ramírez-Fernández, Antonio Tapia-Galisteo, Laura Rubio-Pérez, Marina Gómez-Rosel, Montserrat Grau, José Luis Rodríguez-Peralto, Luis Álvarez-Vallina, Belén Blanco

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ivana ZagoracCancer Immunotherapy Unit, Department of Immunology, Hospital Universitario12 de Octubre, Madrid, Spain.
Ángel Ramírez-FernándezCancer Immunotherapy Unit, Department of Immunology, Hospital Universitario12 de Octubre, Madrid, Spain.
Antonio Tapia-GalisteoCancer Immunotherapy Unit, Department of Immunology, Hospital Universitario12 de Octubre, Madrid, Spain.
Laura Rubio-PérezCancer Immunotherapy Unit, Department of Immunology, Hospital Universitario12 de Octubre, Madrid, Spain.
Marina Gómez-RoselCancer Immunotherapy Unit, Department of Immunology, Hospital Universitario12 de Octubre, Madrid, Spain.
Montserrat GrauAnimal Facility, Instituto de Investigación Sanitaria 12 de Octubre (imas12), Madrid, Spain.
José Luis Rodríguez-PeraltoDepartment of Pathology, Hospital Universitario 12 de Octubre, Madrid, Spain.
Luis Álvarez-VallinaCancer Immunotherapy Unit, Department of Immunology, Hospital Universitario12 de Octubre, Madrid, Spain.
Belén BlancoCancer Immunotherapy Unit, Department of Immunology, Hospital Universitario12 de Octubre, Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In the last decade, c Methods: We have electroporated human primary T cells with Results: STAR Conclusions: Our results strongly support mRNA-engineered TCE-secreting T cells as a promising therapeutic strategy for solid tumors.

Indexed as

Antibodies, BispecificImmunotherapy, AdoptiveNeoplasmsReceptors, Chimeric AntigenRNA, MessengerT-LymphocytesAnimalsCell Line, TumorErbB ReceptorsHumansMiceXenograft Model Antitumor AssaysAntibodies, BispecificErbB ReceptorsReceptors, Chimeric AntigenRNA, MessengerCAR-T cellmRNAsolid tumorsSTAb-T cellSTAR-T cellT cell engager (TCE)

Identifiers

PMID41341587
PMCPMC12669218

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.