Evidence map›Paper›PMID 41341583›Full record

ArticleFrontiers in immunology2025

Zhiyang Jiang, Beichen Jia, Naijing Hu, Mengmeng Zhang, He Xiao, Guojiang Chen, Jijun Yu, Xinying Li, Beifen Shen, Jiannan Feng and 1 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhiyang JiangAcademy of Military Medical Sciences, Beijing, China.
Beichen JiaAcademy of Military Medical Sciences, Beijing, China.
Naijing HuAcademy of Military Medical Sciences, Beijing, China.
Mengmeng ZhangAcademy of Military Medical Sciences, Beijing, China.
He XiaoAcademy of Military Medical Sciences, Beijing, China.
Guojiang ChenAcademy of Military Medical Sciences, Beijing, China.
Jijun YuAcademy of Military Medical Sciences, Beijing, China.
Xinying LiAcademy of Military Medical Sciences, Beijing, China.
Beifen ShenAcademy of Military Medical Sciences, Beijing, China.
Jiannan FengAcademy of Military Medical Sciences, Beijing, China.
Jing WangAcademy of Military Medical Sciences, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transgenic animal bioreactors provide a complementary strategy to traditional mammalian cell culture systems for the production of therapeutic human monoclonal antibodies (mAbs). Here we present a CRISPR/Cas9-mediated breakthrough in creating two novel genetically engineered (GE) mouse models with species-specific chromosomal integration of human anti-staphylococcal enterotoxin B (SEB) mAb genes at either the

Indexed as

Antibodies, NeutralizingEnterotoxinsAnimalsAntibodies, MonoclonalCRISPR-Cas SystemsFemaleGenetic EngineeringGlycosylationHumansMiceMice, TransgenicAntibodies, MonoclonalAntibodies, Neutralizingenterotoxin B, staphylococcalEnterotoxinsCRISPR/Cas9genome-engineered bioreactorsgenomic safe harbors (ROSA26/H11)human monoclonal antibodystaphylococcal enterotoxin B (SEB)

Identifiers

PMID41341583
PMCPMC12669199

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.