ArticleFrontiers in immunology2025
Radon exposure delays the development of skin lesions in a mouse model of psoriasis.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: The chronic inflammatory skin disease psoriasis vulgaris is characterized by itchy plaques, often accompanied by life-threatening comorbidities severely impairing the quality of life and cause high socioeconomic costs. Despite the known cancer risk, radon inhalation is used as a treatment for various chronic inflammatory diseases, including psoriasis. Knowledge about the underlying mechanism is scarce, largely due to the lack of suitable mouse models. Methods: Here, we used transgenic mice that spontaneously develop chronic psoriatic skin lesions inflicted by constitutive low-level IL-17A-production by CD11c Results and discussion: Following multiple radon exposures, plaque formation was significantly delayed in CD11c-IL-17A Conclusion: This study provides the first evidence of the efficacy of radon treatment, including the underlying mechanisms in a preclinical mouse model.
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