ArticleFrontiers in cell and developmental biology2025
Tissue origin dictates functional diversity of BMSC-derived EVs in bone regeneration.
Article in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Bone regeneration is mediated by paracrine signaling, with extracellular vesicles (EVs) playing a crucial role as communication mediators. Previous studies have shown that there are differences in the performance of the bone marrow mesenchymal stem cells (BMSCs) derived from the mandible and limbs. However, it is not clear whether there are differences in EVs originating from them. In this study, we demonstrated that compared to EVs derived from limbs, the EVs derived from the mandible were more effective in stimulating BMSCs migration, proliferation, osteogenic differentiation
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