Evidence map›Paper›PMID 41341488›Full record

ArticlePCN reports : psychiatry and clinical neurosciences2025

Meta-analysis of

Yusuke Takahashi, Naoki Takamatsu, Naohiro Okada, Sho Yagishita, Kiyoto Kasai

Abstract read
In one paragraph

Article in PCN reports : psychiatry and clinical neurosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Meta-analysis ofPCN reports : psychiatry and clinical neurosciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yusuke TakahashiDepartment of Neuropsychiatry Graduate School of Medicine The University of Tokyo Bunkyo-ku Tokyo Japan.
Naoki TakamatsuDepartment of Neuropsychiatry Graduate School of Medicine The University of Tokyo Bunkyo-ku Tokyo Japan.ORCID https://orcid.org/0000-0003-1704-6411
Naohiro OkadaDepartment of Neuropsychiatry Graduate School of Medicine The University of Tokyo Bunkyo-ku Tokyo Japan.ORCID https://orcid.org/0000-0002-8338-2758
Sho YagishitaDepartment of Structural Physiology Graduate School of Medicine, Center for Disease Biology and Integrative Medicine The University of Tokyo Bunkyo-ku Tokyo Japan.
Kiyoto KasaiDepartment of Neuropsychiatry Graduate School of Medicine The University of Tokyo Bunkyo-ku Tokyo Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Schizophrenia spectrum disorders (SSDs) and autism spectrum disorder (ASD) share social-cognitive deficits, genetic architecture, and overlapping animal models, yet the neurochemical signatures that differentiate them remain unclear. This protocol describes a systematic review and meta-analysis of proton magnetic resonance spectroscopy ( Methods: Eligible studies will be those measuring Results: We expect to identify both shared and distinct glutamatergic alterations across SSD subgroups and ASD, with potential stage-specific patterns in cortical and subcortical regions. Conclusions: This comprehensive analysis aims to identify regional brain glutamatergic biomarkers differentiating SSD and ASD. These neurochemical signatures will provide an essential reference framework for validating and guiding reverse-translational research. PROSPERO Registration Number: CRD420251003550.

Indexed as

autism spectrum disorderglutamic acidglutaminemagnetic resonance spectroscopyschizophrenia spectrum and other psychotic disorders

Identifiers

PMID41341488
PMCPMC12670971

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.