ArticlePCN reports : psychiatry and clinical neurosciences2025
A case of Klinefelter syndrome presenting with an acute psychotic episode after COVID-19 infection.
Article in PCN reports : psychiatry and clinical neurosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- A case of Klinefelter syndrome presenting with an acute psychotic episode after COVID-19 infection.PCN reports : psychiatry and clinical neurosciences · 2025Article
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4 authors.
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Abstract
Background: Klinefelter syndrome (KS) is a disease caused by a 47, XXY sex chromosome abnormality. It has been reported that KS not only causes physical problems but also confers the risk of developing psychiatric disorders, such as schizophrenia, bipolar disorder, and autism spectrum disorder. Case Presentation: Here we present a case of an 18-year-old male with complete KS who developed an acute psychotic episode after COVID-19 infection. The patient presented a catatonic state with stupor, rejection of others, and hallucinations that led him to self-injury. Psychotic symptoms improved in about 2 months with an antipsychotic, aripiprazole. Conclusion: To our knowledge, this is the first report of a KS patient who acutely developed a psychotic disorder after COVID-19. Vulnerability to psychotic conditions of KS likely manifests as an acute psychotic episode facilitated by the neurotropic effects of COVID-19.
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