ArticleJournal of cytology
Buccal Cytome Assay in Pesticide-exposed Farm Workers of the Haryana Region: A Biomarker of Cytogenotoxicity.
Article in Journal of cytology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Background: Agriculture is vital to India's economy, with farm workers playing a crucial role. Extensive pesticide use in farming raises concerns about its potential genotoxic effects on workers. Despite India's status as an agricultural hub, research focusing on these risks remains limited. This study aims to investigate the cytogenotoxic effects of pesticides on exfoliated buccal epithelial cells using the buccal cytome assay (BMCyt). Aim: To assess the cytogenotoxic effects of pesticides on farm workers' buccal epithelial cells and to inform healthcare strategies for this occupational hazard. Materials and Methods: A total of 128 male farm workers were divided into four groups (32 per group) based on pesticide exposure and compared with age-matched unexposed controls. Cytologic characteristics, including micronuclei (MN), karyorrhexis (KR), binucleation (BN), pyknosis (P), and karyolysis (KL), were evaluated in PAP-stained slides. Results: The mean frequency of all nuclear anomalies was higher in the pesticide-exposed groups, with the highest observed in those exposed for over 18 years (MN: 9.28 ± 9.14, KR: 5.81 ± 7.18, KL: 15.68 ± 13.16, P: 0.71 ± 1.25, BN: 2.59 ± 2.07), followed by those with less than 18 years of exposure, while unexposed workers had the lowest anomalies. Significant intergroup and intra-group differences were found, highlighting the cumulative effects of prolonged pesticide exposure. Conclusion: The study supports using micronuclei and other nuclear anomalies as screening tools for farm workers, advocating for periodic medical evaluations to protect their health and well-being.
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