Evidence map›Paper›PMID 41341413›Full record

SynthesisFrontiers in physiology2025

Effects of blood flow restrictiontraining on muscle function and balance in chronic ankle instability: a systematic review.

Ziliang Wen, Bing Zheng, Jiang Zhu, Xuelian Wu, Zonghui Wu

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ziliang WenSport Rehabilitation Research Institute of Southwest University, Southwest University, Chongqing, China.
Bing ZhengSport Rehabilitation Research Institute of Southwest University, Southwest University, Chongqing, China.
Jiang ZhuSport Rehabilitation Research Institute of Southwest University, Southwest University, Chongqing, China.
Xuelian WuSport Rehabilitation Research Institute of Southwest University, Southwest University, Chongqing, China.
Zonghui WuSport Rehabilitation Research Institute of Southwest University, Southwest University, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chronic ankle instability (CAI) impairs peri-ankle strength and balance. While blood flow restriction training (BFRT) enhances muscle strength, hypertrophy, and activation, its efficacy in CAI remains uncertain, warranting this systematic review. Methods: This systematic review analyzed randomized controlled trials with BFRT interventions from five databases (PubMed, Scopus, Web of Science, EBSCOhost, CNKI). Relevant data were extracted, and the PEDro Scale was used to assess the methodological quality of each study. Results: Nine studies from four countries were included, involving a total of 263 patients, with publication dates ranging from 2020 to 2024. The PEDro scores of these studies ranged from 6 to 10. Two of the studies demonstrated positive effects on muscle hypertrophy, five showed significant improvements in muscle strength, and four reported enhanced muscle group activation, although there were variations in the activation of specific muscle groups. Of the seven studies assessing balance, one failed to confirm a positive effect. Conclusion: This systematic review demonstrates that blood flow restriction therapy (BFRT) combined with low-intensity conventional rehabilitation training significantly enhances ankle muscle strength and promotes muscle hypertrophy in patients with chronic ankle instability (CAI). Despite variations in training protocols and BFRT parameters across studies, these benefits have been consistently observed in both acute (single-treatment) and short-term (4-6 weeks) interventions. Additionally, most of the included studies underscore the beneficial effects of BFRT on improving muscle activation and balance. However, some of the research results are still inconsistent and require further study. Systematic Review Registration: http://inplasy.com, identifier: INPLASY202490117.

Indexed as

balanceblood flow restriction trainingchronic ankle instabilitymuscle functionsystematic review

Identifiers

PMID41341413
PMCPMC12668957

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.