ArticleFrontiers in oncology2025
Case Report: Clinical pathological characteristics, diagnosis, and treatment analysis of eosinophilic solid and cystic renal cell carcinoma: experience from a five-case series.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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Corrections and comments
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6 authors.
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Abstract
Background: Eosinophilic solid and cystic renal cell carcinoma (ESC-RCC) is a rare renal tumor subtype. Accurate diagnosis and effective management remain challenging due to its distinct but often overlapping features with other renal tumors. This study aims to characterize the clinicopathological features, management, and outcomes of a five-case series to improve diagnostic and therapeutic strategies for this entity. Methods: We retrospectively analyzed five patients with pathologically confirmed ESC-RCC from 2020 to 2025. Data on clinical presentation, imaging, histopathology, immunohistochemistry (IHC), surgical management, and long-term follow-up were collected. Results: The majority of patients (4/5) presented with flank pain. Imaging revealed solitary, well-demarcated cystic-solid masses with progressive enhancement in solid components and a lack of enhancement in cystic areas. Histopathology consistently showed a mixed growth pattern with eosinophilic, hobnail-like cells and distinct perinuclear halos. IHC was crucial for diagnosis, with consistent CK20 Conclusion: ESC-RCC exhibits a unique clinicopathological and immunophenotypic profile. Early detection and complete surgical resection are critical for a favorable outcome. The potential for metastasis and recurrence underscores the need for genetic testing (e.g.,
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