Evidence map›Paper›PMID 41341372›Full record

ArticleActa gastroenterologica Latinoamericana

[Partial External Biliary Diversion in Progressive Familial Intrahepatic Cholestasis and Alagille Syndrome: A Case Series].

Fabian Salgueiro, Carol Lezama Elecharri, Marcela Galoppo, Micaela Wisniacki, María Solaegui, Alejandra Pedreira, Sabrina Torres, Elena De Matteo, Miguel Palmeiro, Pablo Volonté and 1 more

Abstract readEnglish Abstract
In one paragraph

Article in Acta gastroenterologica Latinoamericana. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

11 authors.

Fabian SalgueiroHospital de Niños "Ricardo Gutiérrez". Ciudad Autónoma de Buenos Aires, Argentina. Hospital de Niños Dr. Ricardo Gutiérrez Hospital de Niños "Ricardo Gutiérrez" Ciudad Autónoma de Buenos Aires Argentina.ORCID https://orcid.org/0000-0003-3106-6355
Carol Lezama ElecharriHospital de Niños "Ricardo Gutiérrez". Ciudad Autónoma de Buenos Aires, Argentina. Hospital de Niños Dr. Ricardo Gutiérrez Hospital de Niños "Ricardo Gutiérrez" Ciudad Autónoma de Buenos Aires Argentina.ORCID https://orcid.org/0000-0002-6869-7014
Marcela GaloppoHospital de Niños "Ricardo Gutiérrez". Ciudad Autónoma de Buenos Aires, Argentina. Hospital de Niños Dr. Ricardo Gutiérrez Hospital de Niños "Ricardo Gutiérrez" Ciudad Autónoma de Buenos Aires Argentina.ORCID https://orcid.org/0000-0002-8129-8202
Micaela WisniackiHospital de Niños "Ricardo Gutiérrez". Ciudad Autónoma de Buenos Aires, Argentina. Hospital de Niños Dr. Ricardo Gutiérrez Hospital de Niños "Ricardo Gutiérrez" Ciudad Autónoma de Buenos Aires Argentina.ORCID https://orcid.org/0000-0002-9412-0921
María SolaeguiHospital de Niños "Ricardo Gutiérrez". Ciudad Autónoma de Buenos Aires, Argentina. Hospital de Niños Dr. Ricardo Gutiérrez Hospital de Niños "Ricardo Gutiérrez" Ciudad Autónoma de Buenos Aires Argentina.ORCID https://orcid.org/0000-0003-1722-2067
Alejandra PedreiraHospital de Niños "Ricardo Gutiérrez". Ciudad Autónoma de Buenos Aires, Argentina. Hospital de Niños Dr. Ricardo Gutiérrez Hospital de Niños "Ricardo Gutiérrez" Ciudad Autónoma de Buenos Aires Argentina.ORCID https://orcid.org/0000-0001-9420-0123
Sabrina TorresHospital de Niños "Ricardo Gutiérrez". Ciudad Autónoma de Buenos Aires, Argentina. Hospital de Niños Dr. Ricardo Gutiérrez Hospital de Niños "Ricardo Gutiérrez" Ciudad Autónoma de Buenos Aires Argentina.ORCID https://orcid.org/0000-0002-8418-1579
Elena De MatteoHospital de Niños "Ricardo Gutiérrez". Ciudad Autónoma de Buenos Aires, Argentina. Hospital de Niños Dr. Ricardo Gutiérrez Hospital de Niños "Ricardo Gutiérrez" Ciudad Autónoma de Buenos Aires Argentina.ORCID https://orcid.org/0000-0002-3856-0252
Miguel PalmeiroHospital de Niños "Ricardo Gutiérrez". Ciudad Autónoma de Buenos Aires, Argentina. Hospital de Niños Dr. Ricardo Gutiérrez Hospital de Niños "Ricardo Gutiérrez" Ciudad Autónoma de Buenos Aires Argentina.ORCID https://orcid.org/0000-0001-6070-9124
Pablo VolontéHospital de Niños "Ricardo Gutiérrez". Ciudad Autónoma de Buenos Aires, Argentina. Hospital de Niños Dr. Ricardo Gutiérrez Hospital de Niños "Ricardo Gutiérrez" Ciudad Autónoma de Buenos Aires Argentina.ORCID https://orcid.org/0000-0002-8154-7918
Cristina GaloppoHospital de Niños "Ricardo Gutiérrez". Ciudad Autónoma de Buenos Aires, Argentina. Hospital de Niños Dr. Ricardo Gutiérrez Hospital de Niños "Ricardo Gutiérrez" Ciudad Autónoma de Buenos Aires Argentina.ORCID https://orcid.org/0000-0001-8652-2261

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Partial external biliary diversion in patients with progressive familial intrahepatic cholestasis and Alagille syndrome reduces plasma bile salt levels by modifying their enterohepatic circulation. When this surgical technique is performed before the onset of cirrhosis, the symptoms may improve. It can also modify hepatic fibrosis evolution and, thus, disease progression by avoiding or delaying liver transplantation. We present eight patients undergoing partial external biliary diversion: five patients were diagnosed with progressive familial intrahepatic cholestasis, and three of them with Alagille syndrome and severe pruritus. Presence of cirrhosis was ruled out in all cases after liver biopsy was performed. Two out of five patients with partial external biliary diversion are alive with their native liver and are almost asymptomatic four and twenty years after the procedure respectively. The three patients with Alagille syndrome improved their symptoms; two of them had complete symptom resolution.

Indexed as

Alagille syndromeexternal biliary diversionProgressive familial intrahepatic cholestasis

Identifiers

PMID41341372
PMCPMC12310222

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.