ArticleFrontiers in aging2025
Influence of circadian rhythm on the determination of the IMMune Age indeX (IMMAX).
Article in Frontiers in aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
Corrections and comments
- Erratum issued
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4 authors.
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Abstract
Introduction: To study the impact of immunosenescence on various biological processes the determination of the immune age has gained much interest in recent years. Based on easily determined five immune cell components we recently developed the IMMune Age indeX (IMMAX) as a biomarker for immunosenescence. However, the influence of the circadian rhythm of immune cell concentrations in peripheral blood on the determination of the IMMAX was unclear. Methods: Therefore, we conducted an experimental study with 50 participants aged 20-69 years and took blood samples at 8 a.m., 1 p.m. and 6 p.m. to determine the IMMAX over the day. Additionally, the chronotype of the study participants was assessed by D-MEQ questionnaire. Results: While individual immune cell ratios showed changes during the day, we determined no significant variability of the IMMAX score between the measurements. Interestingly, the individual chronotype influenced the diurnal rhythm of the IMMAX score with morning types showing a decrease of IMMAX values during the day. Conclusion: This longitudinal trial strengthens the IMMAX as a robust biomarker for the immune age independent from time of blood sampling.
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