ArticleFrontiers in cardiovascular medicine2025
Multidirectional wall shear stress is associated with thrombotic risk in isolated coronary artery ectasia.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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12 authors.
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Abstract
Background: Thrombosis is a critical and lethal complication of isolated coronary artery ectasia (iCAE), potentially linked to hemodynamic changes, particularly wall shear stress (WSS) alterations. However, the association between thrombosis and multidirectionality of blood flow, and thus of WSS, is not well defined. Methods: This study retrospectively enrolled 34 patients diagnosed with iCAE. In total, 53 ectatic coronary arteries were identified for hemodynamics analysis, of which 11 had thrombosis and 42 did not. We used an automated workstation for coronary three-dimensional reconstruction and conducted computational fluid dynamics (CFD) analysis. Particularly, we analyzed the mean changes in the following multidirectional WSS metrics at the ectatic segments: time-averaged WSS (TAWSS), oscillatory shear index (OSI), relative residence time (RRT), transverse WSS (transWSS), cross-flow index (CFI), and topological shear variation index (TSVI). Results: Local TAWSS Conclusions: Multidirectional WSS metrics can help identify iCAE with a higher risk of thrombosis. It can improve thrombosis risk stratification.
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