Evidence map›Paper›PMID 41341206›Full record

ArticleJournal of oral microbiology2025

Recognition of

Eisuke Domae, Taiki Mori, Mariko Hanaoka, Takeshi Into

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of oral microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Eisuke DomaeDepartment of Oral Microbiology, Division of Oral Infection Health Sciences, Asahi University School of Dentistry, Mizuho, Gifu, Japan.ORCID https://orcid.org/0000-0001-5493-7980
Taiki MoriDepartment of Oral Microbiology, Division of Oral Infection Health Sciences, Asahi University School of Dentistry, Mizuho, Gifu, Japan.ORCID https://orcid.org/0000-0003-2941-8497
Mariko HanaokaDepartment of Oral Microbiology, Division of Oral Infection Health Sciences, Asahi University School of Dentistry, Mizuho, Gifu, Japan.
Takeshi IntoDepartment of Oral Microbiology, Division of Oral Infection Health Sciences, Asahi University School of Dentistry, Mizuho, Gifu, Japan.ORCID https://orcid.org/0000-0001-9411-9480

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Methods: Standard-grade (ST) and ultrapure-grade (UP) purified PgLPS were tested for CASP4 activation using recombinant CASP4 in fluorogenic and IL-18 assays. PgLPS-CASP4 interactions were examined by pull-down. In HSC-2 cells, IL-18 maturation, gasdermin D cleavage, pyroptosis, and dependence on CASP4 or TLR4 were assessed after cytosolic LPS delivery. Guanylate-binding protein-1 (GBP1) involvement was evaluated by siRNA knockdown. Effects of outer membrane vesicles (OMVs) were also tested. Results: ST-PgLPS directly activated recombinant CASP4, while UP-PgLPS did not. Intracellular delivery of ST-PgLPS induced weak pyroptosis, while UP-PgLPS had no effect. Responses were abrogated by CASP4 inhibition but not by TLR4 inhibition. IFN- Conclusion: CASP4 activation depends on PgLPS purity and host cell priming. GBP1 contributes to PgLPS sensing, and OMVs serve as vehicles for PgLPS delivery to the cytosol.

Indexed as

caspase−4guanylate-binding protein 1interferon-γlipopolysaccharidePorphyromonas gingivalisToll-like receptor 4

Identifiers

PMID41341206
PMCPMC12671432

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.