ArticleResearch in pharmaceutical sciences2025
Preparation of Pluronic F127 hydrogel loaded with BIF1-iRGD recombinant protein for its targeted anti-cancer effects.
Article in Research in pharmaceutical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- BIF-1 expression in human cancers: roles in apoptosis, autophagy, and therapeutic potential.European biophysics journal : EBJ · 2026Review
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4 authors.
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Abstract
Background and purpose: Pluronic F127-based hydrogel is a fair formulation for increasing the protein stability and half-life without decreasing its biological activity. The present study aimed to prepare FP127 hydrogel loaded with the recombinant BIF1-iRGD protein as a new immunotoxin with targeting potential of cancer cells. Experimental approach: BIF1-iRGD in 19% w/v of FP127 was prepared by the cold method, and its Findings/Results: BIFl-iRGD release followed the first-order model. The toxicity of BIFl-iRGD was less than that in the formulation as a hydrogel after 48 and 72 h of treatment. The null hydrogel showed no toxicity compared to the untreated cells. After 24 h, cells treated with BIFl-iRGD-hydrogel and BIFl-iRGD around their 48-h IC Conclusion and implications: BIF-iRGD-hydrogel showed
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