ReviewFrontiers in endocrinology2025
Parathyroid hormone assay standardization in CKD-MBD: resolving heterogeneity for precision medicine.
Review in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Parathyroid hormone (PTH) plays a crucial role in calcium homeostasis and bone metabolism. Accurate measurement of PTH is essential for diagnosing and managing various endocrine and osteological diseases, particularly in the context of chronic kidney disease-mineral and bone disorder (CKD-MBD). Current immunoassays-categorized into three generations-struggle with PTH's molecular heterogeneity. Mass spectrometry (MS) offers structural specificity, with recent advances achieving satisfactory sensitivity for intact 1-84 PTH quantification and identifying clinically relevant fragments. This review synthesizes the technological limitations of PTH measurement methods, highlights the critical standardization challenges, and discusses evolving strategies, including MS, to pave the way for reliable PTH testing in CKD management.
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