ArticleJournal of frailty, sarcopenia and falls2025
Assessment of Frailty Status and Its Association with Heart Rate Variability and Body Composition Among Patients with Type 2 Diabetes Mellitus: A Cross-Sectional Study.
Article in Journal of frailty, sarcopenia and falls, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Exploring heart rate variability as a biomarker for frailty: A narrative review.European journal of clinical investigation · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To evaluate frailty status and its association with heart rate variability (HRV), body composition, and metabolic profile in patients with Type 2 Diabetes Mellitus (T2DM). Methods: In this cross-sectional study, 139 T2DM patients (age 50-65 years) were recruited. Frailty status was classified as non-frail, pre-frail, or frail using the Physical Frailty Phenotype (PFP) criteria. Outcome measures included HRV from a 5-minute ECG, body composition via bioelectrical impedance analysis, and a full metabolic profile. Results: The prevalence of pre-frailty or frailty was 95%. Increasing frailty status was significantly associated with autonomic dysfunction, characterized by reduced parasympathetic and increased sympathetic HRV indices (e.g., higher LF:HF ratio, p=0.003). Frail patients had a significantly higher fat percentage (p=0.015) and lower lean percentage (p=0.015) compared to non-frail participants. Poorer glycemic control (HbA1c: p=0.003) and a more adverse lipid profile were also significantly associated with worsening frailty. Conclusion: Frailty is highly prevalent in this T2DM cohort and is associated with significant adverse changes in autonomic function, body composition, and cardiometabolic health, highlighting the need for a multifaceted management approach.
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