Evidence map›Paper›PMID 41341042›Full record

ArticleACS central science2025

A Viral Neuraminidase-Specific Sensor for Taste-Based Detection of Influenza.

Martina Raschig, Marcus Gutmann, Josef Kehrein, Eberhard Heller, Michael Bomblies, Marcel Groß, Oskar Steinlein, Peggy Riese, Stephanie Trittel, Tessa Lühmann and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS central science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Martina RaschigInstitute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Marcus GutmannInstitute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.ORCID https://orcid.org/0000-0001-6000-7923
Josef KehreinInstitute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.ORCID https://orcid.org/0000-0003-4042-6762
Eberhard HellerInstitute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Michael BombliesInstitute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Marcel GroßInstitute of Organic Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Oskar SteinleinInstitute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Peggy RieseDepartment Vaccinology and Applied Microbiology (VAC), Helmholtz Centre for Infection Research (HZI), 38124 Braunschweig, Germany.
Stephanie TrittelDepartment Vaccinology and Applied Microbiology (VAC), Helmholtz Centre for Infection Research (HZI), 38124 Braunschweig, Germany.
Tessa LühmannInstitute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.ORCID https://orcid.org/0000-0001-7552-6435
Carlos A GuzmánDepartment Vaccinology and Applied Microbiology (VAC), Helmholtz Centre for Infection Research (HZI), 38124 Braunschweig, Germany.
Jürgen SeibelInstitute of Organic Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Heinrich JehleBettackerst. 17, 72636 Frickenhausen, Germany.
Christian LinzFaculty of Medicine and University Hospital Cologne, Department of Oral, Maxillofacial and Plastic Surgery, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.
Stephan HackenbergDepartment of Otorhinolaryngology, Plastic, Aesthetic and Reconstructive Head and Neck Surgery, University Hospital Würzburg, 97080 Würzburg, Germany.
Lorenz MeinelInstitute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.ORCID https://orcid.org/0000-0002-7549-7627

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Influenza has caused the deadliest pandemics in history, thereby prompting advances in our ability to ensure vigilance at all stages of future outbreaks. Quarantining patients early is crucial when it comes to preventing these outbreaks, but it is challenging with influenza due to presymptomatic transmission. Presymptomatic detection translates into massive screening needs, which necessitate cost-effective tools with access for anyone, anywhere, and at any time. We met these challenges by synthesizing sensors that respond to influenza infections with taste generation by using the tongue as an always-available detector. In doing so, we utilized the virus's need for neuraminidase cleavage of α-glycosidic bonds to detect its presence in patients. We synthesized

Identifiers

PMID41341042
PMCPMC12670280

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.