ArticleInfectious medicine2025
Combination of minocycline and ciprofloxacin enhances the inhibitory effect of tumor necrosis factor-alpha production in lipopolysaccharide-stimulated THP-1 monocytic cells.
Article in Infectious medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- A new therapeutic strategy for spotted fever group rickettsioses: a proposal for evaluating combination therapy with tetracycline and fluoroquinolones.Frontiers in cellular and infection microbiology · 2026Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Tetracyclines, such as minocycline (MINO), are widely used in the treatment of infectious diseases. Japanese spotted fever (JSF) is usually treated with MINO. When MINO alone is ineffective in treating severe cases of JSF with complications, patients can be successfully treated with tetracycline combined with a quinolone such as ciprofloxacin (CPFX). However, the mechanisms underlying the efficacy of combination therapies remain unclear. We focused on cytokine suppression caused by antimicrobial agents. Methods: THP-1 cells (2 × 10 Results: MINO or CPFX alone significantly inhibited TNF-α and chemokine production, and their combination exerted an even greater inhibitory effect than either drug alone. Conclusions: Combination therapy with MINO and CPFX enhanced the inhibitory effects on inflammatory cytokine and chemokine production
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