Evidence map›Paper›PMID 41340996›Full record

ArticleACS applied nano materials2025

Mannose Targeting and Hydrophobic Tuning of Polycationic Vectors for Efficient Immunostimulatory CpG Delivery.

Federica Bellato, Greta Bellio, Daniele Asnicar, Rosa Catania, Linda Pecchielan, Lara Marcenta, Marco Zanon, Anna Cielo, Marica Zainotto, Marco Pirazzini and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied nano materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Federica BellatoDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, 35131 Padova, Italy.
Greta BellioDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, 35131 Padova, Italy.
Daniele AsnicarDepartment of Chemical Sciences, University of Padova, Via F. Marzolo 1, 35131 Padova, Italy.
Rosa CataniaSchool of Pharmacy, University of Nottingham, Nottingham NG7 2RD, U.K.ORCID https://orcid.org/0000-0002-4717-808X
Linda PecchielanDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, 35131 Padova, Italy.
Lara MarcentaDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, 35131 Padova, Italy.
Marco ZanonDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, 35131 Padova, Italy.
Anna CieloDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, 35131 Padova, Italy.
Marica ZainottoDepartment of Biomedical Sciences, University of Padova, Via Ugo Bassi 58/B, 35131 Padova, Italy.
Marco PirazziniDepartment of Biomedical Sciences, University of Padova, Via Ugo Bassi 58/B, 35131 Padova, Italy.ORCID https://orcid.org/0000-0003-4127-254X
Alberta FerrariniDepartment of Chemical Sciences, University of Padova, Via F. Marzolo 1, 35131 Padova, Italy.ORCID https://orcid.org/0000-0001-6211-7202
Giuseppe MantovaniSchool of Pharmacy, University of Nottingham, Nottingham NG7 2RD, U.K.ORCID https://orcid.org/0000-0002-0837-0351
Francesca MastrottoDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, 35131 Padova, Italy.ORCID https://orcid.org/0000-0002-2499-5490

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The efficacy of nucleic acid-based therapeutics is often hindered by nuclease degradation and poor cellular uptake. To address these challenges, the complexation with cationic polymers to form polyplexes has been increasingly investigated. In our previous work, we developed a platform technology composed of a mannosylated block for targeting dendritic cells (DCs) via endocytic mannose receptor (CD206), an agmatinyl block for nucleic acid condensation in diblock copolymers (M

Indexed as

cancer vaccinationcationic polymersCpGglycoplexmannose receptor

Identifiers

PMID41340996
PMCPMC12670563

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.