SynthesisFrontiers in surgery2025
Perioperative neurocognitive disorder in colorectal cancer surgery: a systematic review of incidence, mechanisms, and interventions.
Synthesis in Frontiers in surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Glymphatic-meningeal lymphatic system imbalance: a peripheral-to-central inflammatory bridge in perioperative neurocognitive disorders.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Perioperative neurocognitive disorder (PND) represents a significant impediment to postoperative recovery in patients undergoing colorectal cancer surgery, particularly among the elderly. This systematic review synthesizes contemporary evidence on PND incidence, risk stratification, and prophylactic strategies. Methods: Adhering to PRISMA guidelines, 343 records were identified from PubMed, Embase, and Web of Science. Bibliometric profiling delineated influential journals, institutions, and seminal references. Following deduplication and screening, 11 randomized controlled trials (RCTs) met inclusion criteria for systematic analysis. Results: Bibliometric analysis revealed Journal of Geriatric Oncology (impact factor 2.7) and Amphia Hospital (Netherlands) as top contributors. PND incidence ranged from 3.4% to 56% across studies. Key risk factors included advanced age (mean 63-76 years), ASA status II-III, and open surgery. Prophylactic interventions reduced PND: melatonin decreased POD by 20%; dexmedetomidine reduced PND by 10.8%-25%. Fast-track surgery lowered POD by 9.5%. Mechanistically, effective strategies attenuated neuroinflammation (IL-6/TNF-α reduction) and optimized analgesia. Conclusions: Multimodal interventions-especially dexmedetomidine-enhanced analgesia and fast-track protocols-consistently mitigate PND. Standardization of PND assessment tools and diversification of study populations are urgently needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.