ReviewActa gastroenterologica Latinoamericana
[Update on the Physiopathology of Gastroesophageal Reflux Disease].
Review in Acta gastroenterologica Latinoamericana. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
The pathophysiology of gastroesophageal reflux disease is multifactorial. The events involved begin in the stomach and, ascending, affect the gastroesophageal junction and the esophagus. The characteristics of the refluxed material will impact the magnitude of the mucosal damage and the symptomatic perception. There are defensive mechanisms and aggressor factors, which are determinants of the disease. The intensity with which symptoms are perceived is variable in each individual and is determined by a combination of mechanisms modulated by the central and peripheral nervous system, and psychological factors such as hypervigilance. Alterations in esophageal clearance together with the type of refluxed material are probably the major determinants of an erosive reflux disease, while mucosal sensitivity is for symptomatic perception. The development of gastroesophageal reflux disease is the product of an imbalance between the factors mentioned above. Understanding the predominant pathophysiological mechanism allows us to offer the patient the best available treatment.
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