ArticleComputational and structural biotechnology journal2025
Modeling liquid-liquid phase separation and its impact on proteasomal substrate degradation.
Article in Computational and structural biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Bioinformatics and artificial intelligence in genomic data analysis: current advances and future directions.Molecular genetics and genomics : MGG · 2025Review
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3 authors.
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Abstract
The proteasome, central to ubiquitin-proteasome mediated degradation of substrate proteins, undergoes liquid-liquid phase separation (LLPS) during substrate processing. However, the mechanisms governing proteasomal LLPS and its functional interplay with degradation dynamics remain elusive. Here, we developed a reaction-diffusion model with thermodynamic constraints to quantitatively characterize proteasome-associated LLPS mediated by the substrate-shuttling factor Radiation-sensitive 23 homolog B (RAD23B). The model successfully captures experimental LLPS dynamics, revealing a concentration-dependent phase transition boundary influenced by proteasome activity and molecular interactions. Significantly, LLPS was found to have bidirectional (enhancing or suppressing), context-dependent effects on degradation efficiency. This work elucidates regulatory mechanisms and functional roles of LLPS in proteasome-mediated degradation, offering a predictive quantitative model and testable hypotheses for future investigation.
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