Evidence map›Paper›PMID 41340836›Full record

ArticleJournal of contemporary brachytherapy2025

Hybrid inverse treatment planning optimization in gynecologic brachytherapy: Comparison with conventional method.

Hiroyuki Okamoto, Masato Nishitani, Ayaka Nagao, Naoya Murakami, Noriyuki Okonogi, Jun Takatsu, Kotaro Ijima, Satoshi Nakamura, Takahito Chiba, Hiroki Nakayama and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of contemporary brachytherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Hiroyuki OkamotoRadiation Safety and Quality Assurance Division, National Cancer Center Hospital, Tokyo 104-0045, Japan.
Masato NishitaniRadiation Safety and Quality Assurance Division, National Cancer Center Hospital, Tokyo 104-0045, Japan.
Ayaka NagaoDepartment of Radiation Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan.
Naoya MurakamiDepartment of Radiation Oncology, Juntendo University Graduate School of Medicine, Tokyo 113-8431, Japan.
Noriyuki OkonogiDepartment of Radiation Oncology, Juntendo University Graduate School of Medicine, Tokyo 113-8431, Japan.
Jun TakatsuDepartment of Radiation Oncology, Juntendo University Graduate School of Medicine, Tokyo 113-8431, Japan.
Kotaro IjimaDepartment of Radiation Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan.
Satoshi NakamuraRadiation Safety and Quality Assurance Division, National Cancer Center Hospital, Tokyo 104-0045, Japan.
Takahito ChibaRadiation Safety and Quality Assurance Division, National Cancer Center Hospital, Tokyo 104-0045, Japan.
Hiroki NakayamaRadiation Safety and Quality Assurance Division, National Cancer Center Hospital, Tokyo 104-0045, Japan.
Tetsu NakaichiRadiation Safety and Quality Assurance Division, National Cancer Center Hospital, Tokyo 104-0045, Japan.
Takumi SakamotoRadiation Safety and Quality Assurance Division, National Cancer Center Hospital, Tokyo 104-0045, Japan.
Kae OkumaDepartment of Radiation Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan.
Hiroshi IgakiDepartment of Radiation Oncology, National Cancer Center Hospital, Tokyo 104-0045, Japan.
Daisuke OzakiDepartment of Radiology, Gunma University Hospital, Gunma 371-8511, Japan.
Ken AndoDepartment of Radiation Oncology, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.
Tatsuya OhnoDepartment of Radiation Oncology, Gunma University Graduate School of Medicine, Gunma 371-8511, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To investigate a semi-automatic hybrid inverse treatment planning optimization (HIPO) approach for gynecological brachytherapy that preserves the pear-shaped dose distribution without relying on dummy structures. Material and methods: We retrospectively analyzed 29 patients with gynecological cancers, who underwent combined intracavitary and interstitial (IC/IS) brachytherapy. HIPO enables optimization of dwell times for specific applicators, while other applicators are fixed in Oncentra Results: H Conclusions: We recommend applying the modified Manchester system with safe OARs doses as the object of fixation, given its consistency with the conventional pear-shaped dose distribution. The proposed method demonstrated clinically acceptable dose distribution and DVH parameters.

Indexed as

gynecologic brachytherapyHIPOIC/ISinverse planningManchester system

Identifiers

PMID41340836
PMCPMC12669829

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.