Evidence map›Paper›PMID 41340827›Full record

ArticleNeurotrauma reports2025

Mechanical Distention of Organotypic Hippocampal Slice Culture Membranes for High-Throughput

Julia Jagielo-Miller, Caleb Bailey, Samir Patel, Paresh Prajapati, Cassidy Leibold, Patrick Sullivan, Mark Prendergast

Abstract read
In one paragraph

Article in Neurotrauma reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Julia Jagielo-MillerDepartment of Psychology, University of Kentucky College of Arts & Sciences, Lexington, Kentucky, USA.
Caleb BaileySanders-Brown Center on Aging, University of Kentucky College of Medicine, Lexington, Kentucky, USA.
Samir PatelDepartment of Physiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA.
Paresh PrajapatiSanders-Brown Center on Aging, University of Kentucky College of Medicine, Lexington, Kentucky, USA.
Cassidy LeiboldDepartment of Psychology, University of Kentucky College of Arts & Sciences, Lexington, Kentucky, USA.
Patrick SullivanSpinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, Kentucky, USA.
Mark PrendergastDepartment of Psychology, University of Kentucky College of Arts & Sciences, Lexington, Kentucky, USA.

Funding

Sustained eIF5A hypusination at the core of brain metabolic dysfunction in TDP-43 proteinopathiesP20GM148326 · NIGMS · UNIVERSITY OF KENTUCKY · PI Patrick G Sullivan · 2023 to 2026
$10.6M
Mitochondrial Uncoupling Prodrug as a Translational Therapy for TBIR01NS112693 · NINDS · UNIVERSITY OF KENTUCKY · PI KILBAUGH, TODD JUSTEN, SULLIVAN, PATRICK G · 2020 to 2025
$3.3M
BLRD VA I01 BX003405NIGMS NIH HHS P20 GM148326NINDS NIH HHS R01 NS112693
6 · The paper itself

Abstract

Traumatic brain injury (TBI) results from impact to the head that induces both primary and secondary injuries. Secondary injuries are characterized by downstream inflammation, metabolic dysfunction, and cell death manifest from the inflicting primary injury to the head. Secondary injury offers a window for therapeutic interventions, but the multifaceted nature of secondary injury is complicated, necessitating mechanistic tools to screen the efficacy of such interventions. As such, utilizing animal models to define the features of secondary injury mechanisms is critical for medications development. Various animal TBI models employ specialized equipment to recapitulate both primary and secondary injury aspects of human TBI. The organotypic hippocampal slice culture (OHSC) model offers a biological intermediate between live animal and dissociated cell culture models. In OHSC models,

Indexed as

in vitro traumatic brain injuryorganotypic hippocampal slice culturereactive oxygen speciessecondary injurystretch injury

Identifiers

PMID41340827
PMCPMC12670678

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.