ReviewNeurophotonics2025
Cerebral blood flow and energy demand: imaging insights into neurovascular function.
Review in Neurophotonics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Vagal nerve stimulation induces vascular oscillations and enhances long-term learning.iScience · 2026Article
- Glial heterogeneity shapes region-specific angiogenesis and neurovascular integrity in the CNS.Science advances · 2026Article
- Acupuncture for Post-Stroke Cognitive Impairment: Mechanisms and Clinical Evidence (2020-2025).Neuropsychiatric disease and treatment · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The brain depends on highly regulated moment-to-moment changes in regional blood supply to support its energetically demanding cognitive function with a limited energy budget. To efficiently match energetic supply to demand, neural activity rapidly increases regional blood flow. This process, known as neurovascular coupling (NVC), represents a particularly sophisticated form of functional hyperemia in the central nervous system, distinguished by its exceptional spatial precision. This feature of the cerebral vasculature generates a spatial and temporal relationship between neuronal activity and vasomotion. Although NVC is widely accepted to be essential for normal brain function and health, it remains poorly understood how NVC supports neuronal function and cognition. This review describes the current understanding of molecular and cellular mechanisms underlying NVC. We will also discuss the potential physiological functions of neurovascular coupling in normal brain function with a focus on energy supply to neural cells. Finally, the impact of neurovascular dysregulation on neurological disorders and the future outlook will be discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.