ArticleKardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery2025
Effect of glutamine and arginine treatment on the inflammatory response in a rat model of pulmonary contusion.
Article in Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Pulmonary contusion leads to alveolar damage and inflammation, which can progress to acute lung injury and acute respiratory distress syndrome. Glutamine and L-arginine play critical roles in immune regulation and inflammation control, showing potential protective effects in lung injury models. Aim: This study aimed to investigate the effects of glutamine and/or arginine, which play significant roles in the immuno-inflammatory response, on mitigating inflammation in an experimentally induced pulmonary contusion model. Material and methods: Thirty male Wistar Albino rats from the same colony were randomly divided into five groups ( Results: Compared to the untreated trauma group, all treatment groups showed significant histopathological improvement ( Conclusions: Both glutamine and arginine treatments were effective in reducing inflammation following pulmonary contusion. However, combined treatment was less effective than arginine alone.
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