ArticleSmall (Weinheim an der Bergstrasse, Germany)2026
Corneal Nerve Regeneration via MSC-Derived EVs: Tissue Source and Culture Dimensionality Dictate miRNA Cargo and Therapeutic Efficacy.
Article in Small (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- When Macrophages Heal and When They Scar: Timing in Corneal Fibrosis.Life (Basel, Switzerland) · 2026Review
- Review
- Mesenchymal stem cells and derived extracellular vesicles in major respiratory diseases: from multifaceted molecular mechanisms to clinical perspectives.Frontiers in cell and developmental biology · 2026Review
- Exosomes in corneal diseases: advances in diagnosis and therapy.Frontiers in cell and developmental biology · 2026Review
- Corneal Nerve Regeneration via MSC-Derived EVs: Tissue Source and Culture Dimensionality Dictate miRNA Cargo and Therapeutic Efficacy.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors.
Funding
Abstract
Extracellular vesicles (EVs) are emerging as critical mediators of intercellular communication and tissue repair, offering a promising cell-free platform for regenerative therapies. In the cornea, sensory nerves are critical for maintaining epithelial integrity and ocular homeostasis. Nerve injury resulting from trauma, surgery, or disease leads to persistent epithelial defects and impaired vision, with limited treatment options. Here, the neuro-regenerative potential of mesenchymal stem cell-derived EVs (MSC-EVs) isolated from human cornea (Co-MSC) and bone marrow (BM-MSC) cultured under 2D and 3D conditions is investigated. EVs are characterized by nanoparticle tracking analysis, ExoView profiling, and Western blot, and their effects on nerve regeneration are evaluated using primary trigeminal ganglion neurons in vitro and a murine corneal injury model in vivo. EVs from both tissue sources promoted neurite outgrowth; however, 3D-derived EVs demonstrate superior efficacy compared to 2D-derived EVs in vitro and in vivo. Co-MSC-EVs show a consistent trend toward enhanced regenerative effects over BM-MSC-EVs. Small RNA sequencing reveals that EV cargo is influenced by both tissue origin and culture dimensionality, with Co-MSC-EVs enriched in miRNAs regulating the extracellular matrix and immune pathways, while BM-MSC-EVs are enriched in neurotrophic signaling miRNAs. These findings support the rational design of MSC-EV-based therapies for neuro-ophthalmic repair.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.