ArticleThoracic research and practice2025
Bioengineered Humanoid-on-Chip Platforms: Tools for Evaluating the Effects of Environmental Exposure on Human Physiological Barriers.
Article in Thoracic research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Insights into Microbiota-Vaccine Crosstalk in Humans: Mechanisms, Modulators, and Translational Horizons.Vaccines · 2026Review
- The Impact of the Exposome on Epithelial Barriers: New Approach Methodologies for Translational Research.Thoracic research and practice · 2026Article
- The Metabolic Calibration of Female Immune Plasticity: From X-Linked Vulnerability to Precision Metabotyping.Biology · 2026Review
- The gut microbiota-immune-brain axis in post-traumatic stress disorder: mechanistic integration and translational prospects.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Environmental pollutants; bioaerosols, chemicals and micro/nano-plastics (MNPs) can disrupt the mechano-biological processes of the human body, impairing structural, cellular, and molecular functions. Such disruptions may ultimately contribute to the onset of toxicity-associated pharmacokinetic disorders. CASE REPORT: Herein, we highlighted our iPSCs or patient-derived brain, lung, liver and intestinal organoid models, iPSCs-differentiated alveolar epithelial cell (AEC) and brain microvascular endothelial cell (BMVEC) barriers, and their OoC models to evaluate the effect of kinds of exposomes. We successfully characterized SPC+ AECs and CD31+ BMVECs with highly transepithelial electrical resistance values as a gold standart, IBA1+ microglia and CD31+ endothelial cells enriched, cortical plate structured advanced matured functional brain organoids, MUC1+ lung-like organoids, EPCAM+/ALB+ liver organoids and human crypt-derived intestinal organoids (Figure 1). Subsequently, we developed integratable organ-specific OoC models utilizing a layer-by-layer fabrication approach to enable co-culture systems of cells and organoids.
conclusionOur advanced bioengineered models demonstrated that environmental exposures significantly compromised barrier integrity, leading to increased translocation across the tissue construct, reduced cell-organoid viability, and dysregulated expression of inflammatory cytokines and immune cell activity. The resilience of human physiological barriers can be effectively modelled using humanized bioengineering platforms that emulate the dynamic mechanical and biochemical forces present
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.