Evidence map›Paper›PMID 41340161›Full record

ArticleActa neuropathologica communications2025

Spontaneous generation of diverse recombinant prion strains: sulfated glycan cofactors facilitate strain emergence but do not determine specific strain properties.

Nuria L Lorenzo, Hasier Eraña, Enric Vidal, Jorge M Charco, Lucía Parga, Carlos M Díaz-Domínguez, Sonia Veiga, Susana Bravo, Samanta Giler, Mariví Geijo and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nuria L Lorenzo *CIMUS Biomedical Research Institute, University of Santiago de Compostela-IDIS, Santiago de Compostela, Spain.
Hasier Eraña *Prion Research Lab, CIC BioGUNE, Basque Research and Technology Alliance (BRTA), Derio, Spain.
Enric VidalUnitat mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain.
Jorge M CharcoPrion Research Lab, CIC BioGUNE, Basque Research and Technology Alliance (BRTA), Derio, Spain.
Lucía PargaCIMUS Biomedical Research Institute, University of Santiago de Compostela-IDIS, Santiago de Compostela, Spain.
Carlos M Díaz-DomínguezPrion Research Lab, CIC BioGUNE, Basque Research and Technology Alliance (BRTA), Derio, Spain.
Sonia VeigaCIMUS Biomedical Research Institute, University of Santiago de Compostela-IDIS, Santiago de Compostela, Spain.
Susana BravoProteomics Unit, Instituto de Investigaciones Sanitarias de Santiago (IDIS), Santiago de Compostela, Spain.
Samanta GilerUnitat mixta d'Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain.
Mariví GeijoAnimal Health Department, NEIKER-Basque Institute for Agricultural Research and Development , Basque Research and Technology Alliance (BRTA), Derio, Spain.
Jesús R RequenaCIMUS Biomedical Research Institute, University of Santiago de Compostela-IDIS, Santiago de Compostela, Spain. jesus.requena@usc.es.
Joaquín CastillaPrion Research Lab, CIC BioGUNE, Basque Research and Technology Alliance (BRTA), Derio, Spain. jcastilla@cicbiogune.es.

Funding

Instituto de Salud Carlos III AC21_2/00024Joint Program in Neurodegenerative Research, JPND, European Union JPND-2021-650-130Ministerio de Ciencia e Innovación CEX2021-001136-SMinisterio de Ciencia e Innovación, Agencia estatal de Investigación, Spain PID2021-122201OB-C21Ministerio de Ciencia e Innovación, Agencia Estatal de Investigación, Spain PID2020-117465GB-I00Ministerio de Ciencia e Innovación, Agencia Estatal de Investigación, Spain PID2021-1222010B-C22Regional Development Funds, European Union EFA031/01 (NEURO-COOP)
6 · The paper itself

Abstract

Significant advances over the last two decades in the study of in vitro prion formation and propagation have revealed that distinct cofactors can facilitate or induce spontaneous prion misfolding. This, in turn, has raised important questions about the role of cofactors and their potential significance in vivo in prion diseases. Key questions include whether cofactors are necessary for prion infectivity or whether they might play a crucial role in determining strain features without being essential for infection. Grounded in previous work that showed that polyanions such as RNA or dextran sulfate facilitate spontaneous prion misfolding in vitro, we have addressed whether other chemically similar cofactors could expand the diversity of PrP

Indexed as

PolysaccharidesPrion DiseasesPrionsPrPSc ProteinsAnimalsBrainChondroitin SulfatesDextran SulfateMiceMice, TransgenicPentosan Sulfuric PolyesterProtein FoldingChondroitin SulfatesDextran SulfatePentosan Sulfuric PolyesterPolysaccharidesPrionsPrPSc ProteinsCofactorsPMSAPrion diseasesPrion strainsPrPScRecombinant prionsSpontaneous misfoldingSpontaneous prionsStrain diversitySulfated glycans

Identifiers

PMID41340161
PMCPMC12676776

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.